15373-23-6

Basic information

• Product Name: (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate
• Synonyms: (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate
• CAS NO: 15373-23-6
• Molecular Weight: 633.444
• Mol File: 15373-23-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate(15373-23-6)
• EPA Substance Registry System: (2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate(15373-23-6)

Safety Data

• Hazardous Substances Data: 15373-23-6(Hazardous Substances Data)

Upstream product

• 5451-40-1 2,6 dichloropurine 
• 14215-97-5 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose 
• 55057-34-6 2,3,5-tri-O-acetyl-α-D-ribofuranosyl bromide 
• 39925-22-9 2,3,5-Tris-O-acetyl-β-D-ribofuranosyl bromide 
• 918800-27-8 p-tolyl 2,3,5-tri-O-benzoyl-1-thio-β-D-ribofuranoside 
• 69-89-6 xanthine 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 171887-02-8 2-amino-5-{[(dimethylamino)methylene]amino}-4,6-dichloropyrimidine 
• 5991-01-5 2,3,5-(tri-O-benzoyl)-D-ribofuranosyl chloride 

Downstream Products

• 79366-24-8 9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-9H-purine 
• 442516-98-5 2-chloro-6-phenyl-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine 
• 146-77-0 2-Chloroadenosine 
• 162684-68-6 2',3',5'-Tri-O-benzoyl-2-chloro-N-[(R)-1-(thiazolyl)thio-2-propyl]adenosine 
• 155768-97-1 2-chloro-N-(2-phenoxyethyl)adenosine 
• 23558-58-9 2-chloro-N-<1-phenyl-2(R)-propyl>-9-β-D-ribofuranosyl-9H-purin-6-amine 
• 155769-04-3 2-chloro-N-[(R)-2-phenoxy-1-propyl]adenosine 
• 155894-92-1 NNC 21-0074 
• 155769-02-1 2-chloro-N-[(R)-1-phenylthio-2-propyl]adenosine 
• 155769-08-7 2-Chloro-N-[(R)-3-methyl-1-phenoxy-2-butyl]adenosine 
• 155769-10-1 2-chloro-N-[(R)-1-phenylsulphonyl-2-propyl]adenosine 
• 155769-07-6 2-methoxy-N-[(R)-1-phenoxy-2-propyl]adenosine 

Relevant articles and documents

Development of a Novel and Scalable Process for the Synthesis of a Key Cangrelor Intermediate

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A One-Pot Synthesis of Highly Functionalized Purines

Highly substituted purines were synthesized in good to high yields through a one-pot straightforward metal-free scalable method, using the Traube synthesis adapted to Vilsmeier-type reagents. From 5-amino-4-chloropyrimidines, new 9-aryl-substituted chloropurines and intermediates for peptide nucleic acid synthesis were prepared. Variant procedures allowing a rapid synthesis of ribonucleosides and 7-benzylpurine from 5-amidino-6-aminopyrimidines are also reported to illustrate the high potential of this versatile toolbox. This route appears to be particularly interesting in the field of nucleic acids for a direct and rapid access to various new 8-alkylpurine nucleosides.

A general method for N-glycosylation of nucleobases promoted by (p-Tol)2SO/Tf2O with thioglycoside as donor

Based on a preactivation strategy using the (p-Tol)2SO/Tf2O system, a series of nucleosides were synthesized by coupling various thioglycosides with pyrimidines and purines under mild conditions. High yields and excellent β-stereoselectivities were obtained with either armed or disarmed N-glycosylation donors by tuning the amount of (p-Tol)2SO additive.