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Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-4-Phenyl-1-Indanone, 97% is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its high purity level and stability make it a valuable component in the production of these compounds.
Used in Organic Chemistry:
2-Methyl-4-Phenyl-1-Indanone, 97% is used as a key intermediate in the synthesis of a wide range of organic compounds. Its unique molecular structure allows for its incorporation into various chemical reactions, leading to the formation of new and useful molecules.

Upstream product

• 98-80-6 phenylboronic acid 
• 19853-09-9 2-phenylbenzyl bromide 
• 643-58-3 2-methylbiphenyl 
• 95-46-5 2-methylphenyl bromide 
• 108-86-1 bromobenzene 

Relevant academic research and scientific papers

Intramolecular One-Carbon Homologation of Unstrained Ketones via C-C Activation-Enabled 1,1-Insertion of Alkenes

Here, we describe the development of a Rh-catalyzed intramolecular one-carbon homologation of unstrained aryl ketones through a formal 1,1-insertion process of olefins, enabled by temporary directing group (TDG)-aided C-C activation. The reaction provides a distinct approach to access various substituted 1-indanones. Computational mechanistic studies reveal that the formal 1,1-insertion is realized by a selective C(sp2)-C(sp3) activation and turnover limiting 2,1-insertion into the alkene, followed by a facile β-H elimination and reinsertion process.

Binuclear metallocene compound, preparation method and applications thereof

The invention relates to the field of olefin polymerization, and discloses a binuclear metallocene compound, a preparation method and applications thereof, wherein the binuclear metallocene compound has a structure represented by a formula (1). When the binuclear metallocene compound is applied to olefin polymerization as a catalyst component, good catalytic activity can be effectively provided, and a polyolefin product with improved isotacticity is prepared.

Retention and selectivity of teicoplanin stationary phases after copper complexation and isotopic exchange

Teicoplanin is a macrocyclic glycopeptide that is highly effective as a chiral selector for LC enantiomeric separations. Two possible interaction paths were investigated and related to solute retention and selectivity: (1) interactions with the only teicoplanin amine group and (2) role of hydrogen bonding interactions. Mobile phases containing 0.5 and 5 mM copper ions were used to try to block the amine group. In the presence of copper ions, it was found that the teicoplanin stationary phase has a decreased ability to separate most underivatized racemic amino acids. However, it maintained its ability to separate enantiomers that were not α - amino acids. It is established that there is little copper - teicoplanin complex formation. The effect of Cu2+ on the enantioseparation of some α - amino acids appears to be due to the fact that these solutes are good bidentate ligands and form complexes with copper ions in the mobile phase. Isotopic exchange with deuterium oxide was performed using acetonitrile - heavy water mobile phases. It was found that the retention times of all amino acids were lower with deuterated mobile phases. The retention times of polar or apolar molecules without amine groups were higher with deuterated mobiles phases. In all cases, the enantio-selectivity factors were unaffected by the deuterium exchange. It is proposed that the electrostatic interactions are decreased in the deuterated mobile phases and the solute-accessible stationary-phase volume is somewhat swollen by deuterium oxide. The balance of these effects is a decrease in the amino acid retention times and an increase in the apolar solute retention time. The enantio-selectivity factors of all of the molecules remain unchanged because all of the interactions are changed equally. We propose a new global quality criterion (the E factor) for comparing and evaluating enantiomeric separations.