1537547-35-5Relevant academic research and scientific papers
Regioselective synthesis of benzimidazolones via cascade C-N coupling of monosubstituted ureas
Ernst, Johannes B.,Tay, Nicholas E. S.,Jui, Nathan T.,Buchwald, Stephen L.
supporting information, p. 3844 - 3846 (2014/08/05)
A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
