153758-23-7

Upstream product

• 143625-51-8 (3aR,4S,7aR)-2,2-Dimethyl-7-oxo-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-[1,3]dioxolo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester 
• 75772-01-9 [(benzyloxy)methyl](triphenyl)phosphonium chloride 
• 153831-61-9 (4S,5R,6S)-3-<(E)-benzyloxymethylene>-1-(tert-butoxycarbonyl)-6-(trifluoroacetamido)-4,5-(isopropylidenedioxy)piperidine 
• 153758-22-6 (4S,5R,6S)-3-<(Z)-benzyloxymethylene>-1-(tert-butoxycarbonyl)-6-(trifluoroacetamido)-4,5-(isopropylidenedioxy)piperidine 
• 82599-12-0 (benzyloxymethylene)-triphenylphosphorane 

Relevant academic research and scientific papers

Totally synthetic analogues of siastatin B: III - Trifluoroacetamide analogues having inhibitory activity for tumor metastasis

A trifluoroacetamide analogue of siastatin B, (35,45,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxy-3- piperidinecarboxylic acid has been chemically synthesized. This compound, as well as the previously synthesized analogue, (3R,4R,5R,6R)-6-(trifluoroacetamido)-3,4,5- trihydroxy-3-piperidinecarboxylic acid, showed marked inhibitory activity against β-glucuronidase and significant inhibition of experimental pulmonary metastasis of the highly metastatic melanoma B16.