153785-06-9

Upstream product

• 153785-01-4 (R)-2-[(2R,3R)-2-Chlorosulfinyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester 
• 10209-03-7 methyl 6β-phenoxyacetamidopenicillanate-1β-sulfoxide 
• 153784-96-4 (R)-3-Methyl-2-[(2R,3R)-2-(5-methyl-isoxazol-3-ylsulfinamoyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-but-3-enoic acid methyl ester 

Relevant academic research and scientific papers

Amides of 4-oxo-azetidine-2-sulfonic acids and salts thereof, processes for their preparation and their use

The invention relates to the novel 4-oxo-azetidine-2-sulfonic acid amides and their salts of the formula I STR1 wherein the radicals have the meanings: R1 =hydrogen, halogen; R2 =hydrogen, halogen, NH2, C6 H5 CH2 CONH, C6 H5 OCH2 CONH, phthalimido, o-MeNHCOC6 H4 CONH, isoxazolylcarbonylamino; R3 =hydrogen, Me2 C=C--COOMe, H2 C=C(Me)--CH--COOMe, Me2 C=C--COOCH2 C6 H5, H2 C=C(Me)CH--COOCH2 C6 H4 NO2 -p, Me2 C=C--COOCH2 C6 H4 NO2 -p, Me2 C=C--COOCH2 C6 H4 Me-m, H2 C=C(Me)--CH--COOCH2 C6 H4 Me-m, Me2 C=C--COOH; R4 =hydrogen or sodium and R5 =hydrogen, alkyl, benzyl or heterocycle, i.e. isoxazole or pyrazole etc. The invention also relates to the procedure for the preparation thereof and the use thereof as intermediates in the synthesis of beta-lactam analogs or as active components for the preparations of the drugs for antimicrobial therapy.

New Functionalized Monocyclic beta-Lactams Suitable Precursors for Anhydro 2-Azacephams

The anhydro 2-azacephams 9 were prepared starting from penicillanate sulphoxides 1 via 4-aminosulphinyl-2-oxoazetidines 3 and 4-aminosulphonyl-2-oxoazetidines 6 and 8.New functionalized monocyclic beta-lactams 5 and 7 were also produced as precursors for