153786-89-1

Upstream product

• 153786-87-9 3-[(Z)-2-(2-Hydroxymethyl-4,6-dimethoxy-phenyl)-vinyl]-2,2,4-trimethyl-cyclohex-3-enone 
• 173044-49-0 3-(2-Hydroxymethyl-4,6-dimethoxy-phenylethynyl)-2,2,4-trimethyl-cyclohex-3-enone 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 153786-85-7 Acetic acid 3,5-dimethoxy-2-[(E)-2-(6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-en-7-yl)-vinyl]-benzyl ester 
• 153786-86-8 Acetic acid 3,5-dimethoxy-2-[(Z)-2-(6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-en-7-yl)-vinyl]-benzyl ester 
• 173044-52-5 Acetic acid 3,5-dimethoxy-2-(2,6,6-trimethyl-5-oxo-cyclohex-1-enylethynyl)-benzyl ester 
• 153786-84-6 Acetic acid 2-(7-hydroxy-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]dec-7-ylethynyl)-3,5-dimethoxy-benzyl ester 
• 153786-93-7 2-iodo-3,5-dimethoxybenzyl acetate 
• 153786-92-6 7-Ethynyl-6,6,8-trimethyl-1,4-dioxa-spiro[4.5]decan-7-ol 
• 114198-58-2 3,3-(ethylenedioxy)-2,2,6-trimethyl-1-cyclohexanone 
• 38513-65-4 3,5-dimethoxybenzyl acetate 
• 705-76-0 3,5-dimethoxybenzyl alcohol 

Downstream Products

• 173044-53-6 3-[(Z)-2-(2-Hydroxymethyl-4,6-dimethoxy-phenyl)-vinyl]-2,2,4-trimethyl-cyclohex-3-enol 

Relevant academic research and scientific papers

Taxane synthesis through intramolecular pinacol coupling at C-1-C-2. Construction and oxidative transformations of a C-aromatic taxane diene

A ten-linear-step construction of C-aromatic taxane diene 14 from ethylisopropyl ketone, acryloyl chloride, and commercially available 8 is reported. This sequence concludes with an intramolecular pinacol coupling carried out on 13. 14 is oxidized by m-ch

Unusual Oxidative Transformations of a C-Aromatic Taxane Diene and Related Structures

The interaction of 1 and related substances with MCPBA, dimethyldioxirane, VO(acac)2-t-BuOOH, and Mo(CO)6-t-BuOOH affords products with oxygenated A-rings and/or cleaved B-rings through novel oxidative processes.

An AC → ABC approach to taxol involving B-ring closure at C-1-C-2

The treatment of keto aldehyde 13 with low-valent Ti results in a stereoselective intramolecular pinacol coupling that produces taxane synthesis intermediate 14.