1537863-73-2Relevant academic research and scientific papers
ARYL SULTAM DERIVATIVES AS RORc MODULATORS
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Page/Page column 43; 44, (2017/01/26)
Compounds of the formula I: or a pharmaceutical salt thereof, wherein p, s, A, R3 and Re are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
ARYL SULTAM DERIVATIVES AS RORc MODULATORS
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Page/Page column 73, (2017/01/26)
Compounds of the formula I, or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, Het, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein.. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.
HETEROARYL AMIDE SULTAM DERIVATIVES AS RORc MODULATORS
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Page/Page column 49; 50, (2017/07/06)
Compounds of the formula I: (I) or a pharmaceutical salt thereof, wherein m, n, p, q, Het, A, W, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
ARYL SULTAM DERIVATIVES AS RORc MODULATORS
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Paragraph 1227; 1228; 1229, (2016/07/05)
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
Discovery of 1-{4-[3-Fluoro-4-((3 S,6 R)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inver
Fauber, Benjamin P.,René, Olivier,Deng, Yuzhong,Devoss, Jason,Eidenschenk, Céline,Everett, Christine,Ganguli, Arunima,Gobbi, Alberto,Hawkins, Julie,Johnson, Adam R.,La, Hank,Lesch, Justin,Lockey, Peter,Norman, Maxine,Ouyang, Wenjun,Summerhill, Susan,Wong, Harvey
, p. 5308 - 5322 (2015/08/03)
Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse agonists
ARYL SULTAM DERIVATIVES AS RORc MODULATORS
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Paragraph 1219; 1220, (2015/07/22)
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
ARYL SULTAM DERIVATIVES AS RORc MODULATORS
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Page/Page column 101, (2014/02/15)
Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
ARYL SULTAM DERIVATIVES AS RORc MODULATORS
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Page/Page column 45; 46, (2015/01/07)
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, Ar, A, W, X1, X2, X3, X4, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
