1537866-49-1 Usage
Description
(3R,5S,6R,7R,10S,13R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol is a complex organic compound with a unique molecular structure. It is characterized by its multiple chiral centers and functional groups, which contribute to its specific properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(3R,5S,6R,7R,10S,13R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol is used as an impurity in the production of obeticholic acid (E899810) for the treatment of primary biliary cholangitis and is under development for several other liver-related diseases. Its presence in the synthesis process of obeticholic acid highlights its importance in the pharmaceutical industry.
Used in Chemical Research:
Due to its complex structure and multiple chiral centers, (3R,5S,6R,7R,10S,13R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol can be used as a research compound in the field of organic chemistry. It may serve as a starting material or a target molecule for the development of new synthetic methods, chiral catalysts, or as a probe for understanding the behavior of complex molecules in various chemical reactions.
It is important to note that the specific applications and uses of this compound may vary depending on the context and the requirements of the industry or research field. Further investigation and experimentation would be necessary to fully understand its potential and limitations.
Check Digit Verification of cas no
The CAS Registry Mumber 1537866-49-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,3,7,8,6 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1537866-49:
(9*1)+(8*5)+(7*3)+(6*7)+(5*8)+(4*6)+(3*6)+(2*4)+(1*9)=211
211 % 10 = 1
So 1537866-49-1 is a valid CAS Registry Number.
1537866-49-1Relevant articles and documents
Synthesis and characterization of new impurities in obeticholic acid
Feng, Wei-Dong,Zhuo, Song-Ming,Zhang, Fu-Li
, p. 522 - 530 (2019)
Novel and efficient synthetic strategies are developed for the first synthesis of two new impurities found in obeticholic acid. The synthetic routes to the impurities are designed without column purification using 4-nitrobenzoyl chloride as a selective pr
Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors
D'Amore, Claudio,Di Leva, Francesco Saverio,Sepe, Valentina,Renga, Barbara,Del Gaudio, Chiara,D'Auria, Maria Valeria,Zampella, Angela,Fiorucci, Stefano,Limongelli, Vittorio
, p. 937 - 954 (2014/03/21)
Bile acids exert genomic and nongenomic effects by interacting with membrane G-protein-coupled receptors, including the bile acid receptor GP-BAR1, and nuclear receptors, such as the farnesoid X receptor (FXR). These receptors regulate overlapping metabolic functions; thus, GP-BAR1/FXR dual agonists, by enhancing the biological response, represent an innovative strategy for the treatment of enteroendocrine disorders. Here, we report the design, total synthesis, and in vitro/in vivo pharmacological evaluation of a new generation of dual bile acid receptor agonists, with the most potent compound, 19, showing promising pharmacological profiles. We show that compound 19 activates GP-BAR1, FXR, and FXR regulated genes in the liver, increases the intracellular concentration of cAMP, and stimulates the release of the potent insulinotropic hormone GLP-1, resulting in a promising drug candidate for the treatment of metabolic disorders. We also elucidate the binding mode of the most potent dual agonists in the two receptors through a series of computations providing the molecular basis for dual GP-BAR1/FXR agonism.
