1537896-64-2Relevant academic research and scientific papers
A oligosaccharide compounds in the application of neural protection
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, (2017/04/03)
The invention relates to an oligose type compound (including mannose oligose, inositol oligose and maltose oligose) shown in formula (I), as well as the application of stereisomer, tautomer, solvate or prodrug of the oligose type compound in neuroprotection. In formula (I), n represents an integer of 0 or within 1-5.
Synthesis and bioassay of β-(1,4)-D-mannans as potential agents against Alzheimer's disease
Jiang, Ru-Wei,Du, Xiao-Guang,Zhang, Xuan,Wang, Xin,Hu, Ding-Yu,Meng, Tao,Chen, Yue-Lei,Geng, Mei-Yu,Shen, Jing-Kang
, p. 1585 - 1591 (2014/08/05)
Aim: Oligomannurarate 971 derived from a marine plant has shown neuroprotective effects. In this study we synthesized a series of truncated derivatives of the oligosaccharide, and investigated the effect of these derivatives against Aβ peptide toxicity in vitro. Methods: The sulfoxide method was applied to synthesize the derivatives. SH-SY5Y human neuroblastoma cells were treated with A β 1-40 (2 μmol/L), and the cell viability was detected using a CCK8 assay. Results: A series of β-(1,4)-D-mannosyl oligosaccharide, ranging from the disaccharide to the hexasaccharide, were synthesized. Addition of 10 μmol/L β-(1,4)-D-mannobiose 6, β-(1,4)-D-mannotriose 9 or P-(l,4)-D-mannotetraose 12 in SH-SY5Y cells significantly attenuated Aβ1-40-induced toxicity. The efficacies were similar to those caused by 10 μmol/L oligomannurarate 971 or alzhemed. Other oligosaccharides including oligomaltoses and oligocelluloses were less active. Conclusion: Synthetic homogeneous short chain β-(1,4)-D-mannans shows neuroprotective effect against Aβ peptide toxicity similar to that of heterogeneous oligomannurarate 971 and alzhemed.
