1537897-84-9Relevant academic research and scientific papers
Highly regio- and diastereoselective synthesis of cf3- substituted lactones via photoredox-catalyzed carbolactonization of alkenoic acids
Yasu, Yusuke,Arai, Yusuke,Tomita, Ren,Koike, Takashi,Akita, Munetaka
supporting information, p. 780 - 783 (2014/03/21)
Trifluoromethylative lactonization of both terminal and internal alkenoic acids by photoredox catalysis has been developed. The use of a Ru photocatalyst and Umemoto's reagent as a CF3 source is key in the present carbolactonization. This is the first example of a highly endo- and diastereoselective synthesis of CF3-substituted five-, six-, and seven-membered ring lactones from internal alkenoic acids.
