1537906-49-2

Usage

Physical state

Yellow crystalline solid

Molecular weight

220.24 g/mol

Common uses

Building block in the synthesis of pharmaceuticals and organic compounds

Additional uses

Reagent in chemical reactions, flavor and fragrance ingredient

Investigated properties

Antimicrobial and anticancer activities

Industrial and research applications

Unique chemical structure and properties

Upstream product

• 1537906-91-4 C₂₆H₂₈FN 
• 1537906-65-2 C₁₉H₂₁F₂N 
• 4294-57-9 para-methylphenylmagnesium bromide 

Relevant academic research and scientific papers

COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I) wherein: Ak1 represents an alkyl chain, X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)—, —N(R)—CH2— or —CH2—N(R)—CH2—, m and R are as defined in the description, R1 and R2 each represent H when X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)— or —N(R)—CH2—, or together form a bond when X represents —CH2—N(R)—CH2—, R3 represents NH2, Cy-NH2, Cy-Ak3-NH2 or piperidin-4-yl, Cy and Ak3 are as defined in the description, R4 and R5, which may be identical or different, each represent H or F, their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating conditions requiring a TAFIa inhibitor.

Selective alkylation and arylation of C-F bond with grignard reagents

Selective alkylation and arylation of the C-F bonds of polyfluoroaryl imines with Grignard reagents were discovered in the absence of metal catalysts. The aldazine-N atom as an anchoring group has a special effect on the regioselectivity of the reaction. The Ci - N bond addition reaction with Grignard reagents was also explored. A possible mechanism was proposed on the competition between the nucleophilic substitution and addition reaction.