1537907-22-4

Basic information

• Product Name: C₂₆H₂₉N₃O₂S
• CAS NO: 1537907-22-4
• Molecular Weight: 447.601
• Mol File: 1537907-22-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₉N₃O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₉N₃O₂S(1537907-22-4)
• EPA Substance Registry System: C₂₆H₂₉N₃O₂S(1537907-22-4)

Safety Data

• Hazardous Substances Data: 1537907-22-4(Hazardous Substances Data)

Upstream product

• 1537907-14-4 C₂₂H₁₈F₃N₃O₃S 
• 91-56-5 indole-2,3-dione 
• 163068-05-1 3-(trifluoroacetyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7-amine 
• 1537907-15-5 C₂₀H₁₉N₃O₂S 
• 108-94-1 cyclohexanone 

Relevant articles and documents

1-Thia-4,7-diaza-spiro[4.4]nonane-3,6-dione: A Structural Motif for 5-hydroxytryptamine 6 receptor antagonism

A series of potent 5-hydroxytryptamine 6 (5-HT6) receptor antagonists based on 1-thia-4,7-diaza-spiro[4.4]nonane-3,6-dione motif has been disclosed. Enantiomers of potent racemate compound 8a (Ki = 26 nm) displayed difference in activity (Ki of 15 nm versus 855 nm) signaling the influence of the stereochemistry of the chiral center on potency. In addition, the potent enantiomer displayed significant selectivity in biological activities over several related family members. Based on HTS-hit compound 1a (Ki=5.73uM against h5-HT6),compound 8a (Ki=26nM) was developed. Enantiomers (Ki of 15nM vs,855nM)displayed effect of chirality on activity.