1538-97-2

Upstream product

• 3405-89-8 2-(4-chloro-phenylsulfonyl)acetic acid 
• 91715-97-8 N--urethan 
• 3024-31-5 N-(p-Chlorphenylsulfonylmethyl)-N-nitroso-urethan 

Downstream Products

• 5943-04-4 chloromethyl p-chlorophenyl sulfone 
• 2881-11-0 p-Chlorphenylsulfonylformaldehydtriphenylphosphazin 
• 91817-01-5 Toluene-4-sulfonic acid 4-chloro-benzenesulfonylmethyl ester 

Relevant academic research and scientific papers

A method for synthesis of diazo methane compounds

The invention provides a synthetic method of a diazomethane compound. Diazotized sulfonyl-3,5,5-trimethyl-2-cyclohexenyl acetate is decarboxylated under the action of neutral alumina to obtain the high-purity and high-yield diazomethane compound. The synthetic method is carried out without using nitrosyl chloride which has the characteristics of high toxicity and easy blasting as a reaction raw material is environmentally-friendly and safe. The reaction yield is good, all the reactions are carried out with the temperature in a range from 0 to room temperature, and requirements on energy are low. The posttreatment process of the final product is simple, so expensive silica gel column chromatography separation is avoided. The reactant alumina has the effects of impurity separation and product purification, so the high-purity sulfonyl diazomethane derivative can be obtained through simple reduced pressure pumping filtration and concentration.