153813-81-1

Basic information

• Product Name: 3-(diMethylaMino)-1-(3-nitrophenyl)prop-2-en-1-one
• Synonyms: 3-(diMethylaMino)-1-(3-nitrophenyl)prop-2-en-1-one;3-(Dimethylamino)-1-(2-nitrophenyl)prop-2-en-1-one
• CAS NO: 153813-81-1
• Molecular Formula: C₁₁H₁₂N₂O₃
• Molecular Weight: 220.22458
• Mol File: 153813-81-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(diMethylaMino)-1-(3-nitrophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(diMethylaMino)-1-(3-nitrophenyl)prop-2-en-1-one(153813-81-1)
• EPA Substance Registry System: 3-(diMethylaMino)-1-(3-nitrophenyl)prop-2-en-1-one(153813-81-1)

Safety Data

• Hazardous Substances Data: 153813-81-1(Hazardous Substances Data)

Upstream product

• 577-59-3 2-acetylnitrobenzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 931114-28-2 [7-(2-amino-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-thiophen-2-yl-methanone 
• 1380520-65-9 (2E,3E)-dimethyl 2-((dimethylamino)methylene)-3-(2-(2-nitrophenyl)-2-oxoethylidene)succinate 
• 1335517-37-7 1-(2-hydroxyethyl)-5-(2-nitrophenyl)-1H-pyrazole 
• 59844-05-2 5-(2-nitrophenyl)-1H-pyrazole 
• 111562-32-4 5-(2-aminophenyl)-1H-pyrazole 
• 1335517-78-6 5-[2-(isopropylamino)phenyl]-1-phenyl-1H-pyrazole 
• 1335517-74-2 4-nitro-5-(2-nitrophenyl)-1-phenyl-1H-pyrazole 
• 1335517-72-0 3-nitro-5-(2-nitrophenyl)-1-phenyl-1H-pyrazole 
• 1335517-69-5 4-bromo-5-(2-nitrophenyl)-1-phenyl-1H-pyrazole 
• 1335637-76-7 5-(2-aminophenyl)-1-cyclohexyl-1H-pyrazole 
• 1335517-68-4 5-(2-aminophenyl)-1-(4-methoxyphenyl)-1H-pyrazole 

Relevant articles and documents

Carboline derivative/analogue as well as preparation method and application thereof

The invention belongs to the field of chemical medicines, and provides a compound shown as a formula I or pharmaceutically acceptable salt thereof. The invention also provides analogues of the compound as shown in the formula I in the specification. Biological experiments show that the compound disclosed by the invention has anti-tumor activity and serves as a good tubulin inhibitor; the compound91b has excellent antitumor activity, can effectively promote degradation of tubulin; drug resistance caused by overexpression of beta-tubulin III and P-gp can be eliminated, and a new choice is provided for clinical medication.

HYPOXIA-INDUCIBLE FACTOR 1 (HIF-1) INHIBITORS

Embodiments of small molecule inhibitors of hypoxia inducible factor 1 (HIF-1) and pharmaceutical compositions thereof are disclosed. The disclosed compounds suppress HIF-1 activity by inhibiting the interaction between the HIF- 1 α subunit and transcriptional co-activator protein p300. Embodiments of methods for making and using the small molecule inhibitors are also disclosed.

An straightforward entry to new pyrazolo-fused dibenzo[1,4]diazepines

A series of novel pyrazolodibenzo[1,4]diazepines has been synthesized with good overall yields. The diarylpyrazole intermediates, with structure similarity to biologically relevant compounds such as currently marketed drugs like rimonabant or celecoxib, were prepared by a tandem sequence amine-exchange/ heterocyclization starting from readily available enaminones and arylhydrazines. The key step of this efficient methodology was Caryl-N bond construction, accomplished by a palladium-catalyzed intramolecular N-arylation reaction, which was conducted in both homogeneous and polymer-supported versions. Reaction scope of such protocols and recycling of the heterogeneous catalyst were also examined.