153836-33-0

Basic information

• Product Name: (2S,4S)-4-(4-methoxybenzylthio)-1-methyl-2-[3-(4-nitrobenzyloxycarbonylamino)azetidin-1-ylcarbonyl]pyrrolidine
• Synonyms: (2S,4S)-4-(4-methoxybenzylthio)-1-methyl-2-[3-(4-nitrobenzyloxycarbonylamino)azetidin-1-ylcarbonyl]pyrrolidine
• CAS NO: 153836-33-0
• Molecular Weight: 514.602
• Mol File: 153836-33-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,4S)-4-(4-methoxybenzylthio)-1-methyl-2-[3-(4-nitrobenzyloxycarbonylamino)azetidin-1-ylcarbonyl]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-4-(4-methoxybenzylthio)-1-methyl-2-[3-(4-nitrobenzyloxycarbonylamino)azetidin-1-ylcarbonyl]pyrrolidine(153836-33-0)
• EPA Substance Registry System: (2S,4S)-4-(4-methoxybenzylthio)-1-methyl-2-[3-(4-nitrobenzyloxycarbonylamino)azetidin-1-ylcarbonyl]pyrrolidine(153836-33-0)

Safety Data

• Hazardous Substances Data: 153836-33-0(Hazardous Substances Data)

Upstream product

• 127423-28-3 (2S,4S)-4-(4-methoxy-benzylthio)-1-methyl-2-pyrrolidinecarboxylic acid 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 153836-32-9 (2S,4S)-2-(3-aminoazetidin-1-ylcarbonyl]-4-(4-methoxybenzylthio)-1-methylpyrrolidine 

Downstream Products

• 153836-34-1 (2S,4S)-4-mercapto-1-methyl-2-[3-(4-nitrobenzyloxycarbonylamino)azetidin-1-yl-carbonyl]pyrrolidine 
• 153836-85-2 4-nitrobenzyl (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[(2S,4S)-1-methyl-2-[3-(4-nitrobenzyloxycarbonylamino)azetidin-1-ylcarbonyl]pyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylate 

Relevant articles and documents

Synthesis and antibacterial activity of novel 1 β-methyl carbapenems with cycloalkylamine moiety at the C-2 position

Novel 1β-methyl carbapenems with a cycloalkylamine moiety as a side chain were synthesized and their structure-activity relationships were studied. These carbapenems showed potent antibacterial activities against a wide range of range of Gram-positive and Gram-negative bacteria, and moderate urinary recovery when administered intraperitoneally in mice.

Antimicrobial carbapenem derivatives, their preparation and their therapeutic use

Compounds of formula (I): (in which R1 is hydrogen or methyl, R2 is hydrogen, optionally substituted aliphatic hydrocarbon or acylimidoyl, R3 is hydrogen or an ester group, and Q is an optionally quaternized nitrogen-containing group) are useful antibiotics which are resistant to dehydropeptidase I, and are thus useful for the treatment of many microbial infections.