153853-40-8

Upstream product

• 7147-77-5 5-(4-nitrophenyl)-2-furaldehyde 
• 122-00-9 para-methylacetophenone 
• 98-01-1 furfural 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 433925-30-5 2-bromo-3-[5-(4-nitro-phenyl)-furan-2-yl]-1-p-tolyl-propenone 
• 433925-27-0 2,3-dibromo-3-[5-(4-nitro-phenyl)-furan-2-yl]-1-p-tolyl-propan-1-one 
• 294636-03-6 5-[5-(4-nitro-phenyl)-furan-2-yl]-3-p-tolyl-4,5-dihydro-1H-pyrazole 

Relevant academic research and scientific papers

Studies on nitrophenylfuran derivatives part Xii. synthesis, characterization, antibacterial and antiviral activities of some nitrophenylfurfurylidene-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.

Synthesis of four 1-aryl-3-[5-(p-nitrophenyl)-2-furyl]-2-propen-1-ones starting from substituted acetophenones and p-nitrophenylfurfuraldehyde is described. These propenones were then converted into corresponding dibromo derivatives which on dehydrobromin

Synthesis and antioxidant activity study of pyrazoline carrying an arylfuran/arylthiophene moiety

A novel series of N-acetyl-3-aryl-5-(5-(p/o-nitrophenyl)-2-furyl/ /thienyl)-substituted pyrazolines (3a-o) were synthesized by the reaction of 1-aryl-3-(5-(p/o-nitrophenyl)-2-furyl/thienyl)-2-propene-1-ones with hydrazine hydrate in acetic acid medium. The structures of the newly synthesized compounds were established by IR, 1 H-NMR, mass spectra and a single-crystal X-ray study. The antioxidant activities of the synthesized compounds were determined using the DPPH scavenging assay. The compounds 3a, 3f, 3h and 3o showed moderate activity.

Synthesis of 1,3,5-trisubstituted pyrazolines as antimicrobial. and antiinflammatory agents

A series of pyrazolines (2a-j) have been synthesized and evaluated for their antimicrobial and antiinflammatory activities. The structures of the synthesized compounds have been confirmed on the basis of physical and spectral data. Compounds 2b, 2c, 2e and 2g have shown moderate antibacterial activity. None of the synthesized compounds showed antifungal activity. Compounds 2b and 2c exhibited significant antiinflammatory activity.

Studies on arylfuran derivatives Part X. Synthesis and antibacterial properties of arylfuryl-Δ2-pyrazolines

Arylfurylpropenones 3 were synthesized by Claisen-Schmidt condensation of arylfurfurals 1 with various substituted acetophenones 2. Cyclocondensation of these arylfurylpropenones 3 with hydrazine hydrate and phenylhydrazine furnished 1H-pyrazolines 4 and N-phenylpyrazolines 6, respectively. In order to study the structure-activity relationships, pyrazolines 4 were converted into their N-acetyl derivatives 5. The antibacterial properties of the new pyrazoline derivatives were studied. (C) 2000 Elsevier Science S.A.