1538596-03-0Relevant academic research and scientific papers
Synthesis of 1-haloethenamides from ynamide through halotrimethylsilane- mediated hydrohalogenation
Ohashi, Kazuhiro,Mihara, Shigenori,Sato, Akihiro H.,Ide, Masataka,Iwasawa, Tetsuo
supporting information, p. 632 - 635 (2014/01/23)
A convenient synthesis of 1-haloethenamides has been achieved by utilizing halotrimethylsilane (TMSX, X = Cl, Br, I) and water. Halotrimethylsilane in 1 M CH2Cl2 solution functions as a halogen source of the in situ generated HX, and the HX added to the terminal triple bonds of ynamides in Markovnikov fashion.
