15386-85-3

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 106109-76-6 methyl 3-oxo-3-(3-(trifluoromethyl)phenylamino)propanoate 
• 69563-05-9 (3-Trifluoromethyl-phenyl)-trimethylsilanyl-amine 

Downstream Products

• 850798-01-5 N-(3-ethylcarboxyl-phenyl)-N'-(3-trifuoromethyl-phenyl)-malonamide 
• 850797-58-9 N-phenyl-N'-(3-trifuoromethyl-phenyl)-malonamide 
• 850797-90-9 N-(2-chloro-pyridin-4-yl)-N'-(3-trifuoromethyl-phenyl)-malonamide 
• 850798-35-5 N-(quinolin-6-yl)-N'-(3-trifluoromethyl-phenyl)-malonamide 
• 850797-84-1 N-(1H-indol-5-yl)-N'-(3-trifuoromethyl-phenyl)-malonamide 
• 1060674-14-7 2-chloro-N-(4-methoxyphenyl)-3-nitro-7-(trifluoromethyl)quinolin-4-amine 
• 1060673-50-8 3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol 
• 1060674-17-0 2-chloro-N₄-(4-methoxyphenyl)-7-(trifluoromethyl)quinoline-3,4-diamine 

Relevant academic research and scientific papers

New imidazolo-heteroaryl derivatives with antibacterial properties

The invention relates to Imidazolo-heteroaryl derivatives of formula (I) The compounds inhibit the activity of the Dlta enzyme of Gram-positive bacteria and are useful to treat Gram-positive bacterial infections. Furthermore the application discloses method for assessing the Dlta inhibitory activity of tested molecules and a method for measuring the efficacy of molecules in inhibiting bacteria proliferation in vitro.

SUBSTITUTED 2-ARYLMETHYLENE-N-ARYL-N'-ARYL-MALONAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS

The present invention is directed to substituted 2-arylmethylene-N-aryl-N'-aryl-malonamides and analogs thereof. The present invention also relates to the discovery that the compounds are activators of caspases and inducers of apoptosis. Therefore, the activators os caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of anormal cells occurs.

MALONAMIDE DERIVATIVES

The present invention relates to malonamide derivatives of formula (I): A-D-B, the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

REACTION OF TRIMETHYLSILYL DERIVATIVES WITH MELDRUM'S ACID : A NEW AND EASY MONOFUNCTIONALIZATION OF MALONIC ACID

Treament of Meldrum's acid with silylated derivatives (amines, lactams or alcohols) yields very easily monofunctionalized malonic silyl esters.Hydrolysis of these silyl esters leads to the corresponding monoacids with a very good yield.