153876-75-6Relevant academic research and scientific papers
Carbostyril derivatives and antiallergic agent
-
, (2008/06/13)
1. A compound of the formula: STR1 wherein the symbol of a solid line with a broken line means a single bond or a double bond,R and R'' are independently selected from the group consisting of hydrogen atom, halogen atom, lower alkyl, nitro, unsubstituted amino and substituted amino,A and B are independently selected from the group consisting of hydrogen atom, lower alkyl optionally substituted with a lower cycloalkyl, aryl optionally substituted with one or more halogen atoms and the group: -Y-R 2wherein Y is lower alkylene and R 2 is the group: STR2 wherein m is integer of 1 to 3, n is 0 or 1, Z is >N-, >CH-- or >C=, R 3 is diaryl (lower) alkyl optionally substituted with one or more halogen atoms or is condensed heterocyclic group optionally substituted with oxo, with the proviso that(a) at least one of A and B is the group -Y-R 2 and(b) when A is hydrogen atom and B is the group -Y-R 2, then Z is >CH-- or >C= if R 3 is condensed heterocyclic group optionally substituted with oxo and n is Oor a pharmaceutically acceptable salt thereof. The compounds of the above formula have antiallergic activity.
