1539275-42-7

Basic information

• Product Name: N'-(2,3-dihydroxybenzylidene)-4-hydroxybenzohydrazide
• Synonyms: N'-(2,3-dihydroxybenzylidene)-4-hydroxybenzohydrazide
• CAS NO: 1539275-42-7
• Molecular Formula: C14H12N2O4
• Molecular Weight: 272.25608
• Mol File: 1539275-42-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 8.29±0.40(Predicted)
• CAS DataBase Reference: N'-(2,3-dihydroxybenzylidene)-4-hydroxybenzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(2,3-dihydroxybenzylidene)-4-hydroxybenzohydrazide(1539275-42-7)
• EPA Substance Registry System: N'-(2,3-dihydroxybenzylidene)-4-hydroxybenzohydrazide(1539275-42-7)

Safety Data

• Hazardous Substances Data: 1539275-42-7(Hazardous Substances Data)

Upstream product

• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 5351-23-5 4-hydroxybenzoic acid hydrazide 

Relevant articles and documents

Synthesis, crystal structures and luminescent properties of tetranuclear Zn molecular clusters with aroylhydrazone ligand

Two kinds of tetranuclear Zn(ii) molecular clusters with the designed aroylhydrazone Schiff base ligand (H3L), [Zn4(HL) 4]·3(DMF)·3(H2O) (1) and [Zn 4(HL)2(CH3COO)4]·2

Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies

Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1–29) was

Identification of PDZ ligands by docking-based virtual screening for the development of novel analgesic agents

Disrupting the interaction between the PDZ protein, PSD-95, and its target ligands (such as the glutamate NMDA receptor or the serotonin 5-HT2A receptor) was found to reduce hyperalgesia in various models of neuropathic pain. Here, we set out to identify lead molecules which would interact with PSD-95, and hence, would potentially display analgesic activity. We describe the virtual screening of the Asinex and Cambridge databases which together contain almost one million molecules. Using three successive docking filters and visual inspection, we identified three structural classes of molecules and synthesized a potential lead compound from each class. The binding of the molecules with the PDZ domains of PSD-95 was assessed by 1H-15N HSQC NMR experiments. The analgesic activity of the best ligand, quinoline 2, was evaluated in vivo in a model of neuropathic pain and showed promising results.