1539291-91-2Relevant academic research and scientific papers
Substrate control in enantioselective and diastereoselective aldol reaction by memory of chirality: A rapid access to enantiopure β-hydroxy quaternary α-amino acids
Viswambharan, Baby,Gori, Didier,Guillot, Regis,Kouklovsky, Cyrille,Alezra, Valerie
supporting information, p. 788 - 791 (2014/03/21)
An asymmetric aldol reaction by memory of chirality is reported with a substrate control of stereoselectivity by aldehyde and rationalized. Starting from l-alanine, several diastereopure and enantioenriched β-hydroxy quaternary α-amino acids have been obtained in three steps. The initial chirality of l-alanine is memorized through the dynamic axial chirality of tertiary aromatic amide.
