1539320-65-4

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 2666-93-5 (S)-Leu-OMe 
• 15136-16-0 tert-butyl (2S)-2-{[(2S)-1-methoxy-4-methyl-1-oxopentan-2-yl]carbamoyl}pyrrolidine-1-carboxylate 
• 42382-99-0 L-proline-L-leucine methyl ester 
• 1539320-52-9 (S)-methyl 2-((S)-1-(2-((tert-butoxycarbonyl)amino)benzoyl)pyrrolidine-2-carboxamido)-4-methylpentanoate 
• 13734-41-3 t-Boc-L-valine 
• 1539320-53-0 C₁₉H₂₇N₃O₄ 

Downstream Products

• 1539320-44-9 (S)-N-((S)-4-methyl-1-(methylamino)-1-oxopentan-2-yl)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamide 
• 1539320-68-7 C₂₄H₃₆N₄O₅ 
• 1539320-73-4 (S)-methyl 4-methyl-2-((S)-1-(2-((S)-3-methyl-2-pivalamidobutanamido)benzoyl)pyrrolidine-2-carboxamido)pentanoate 

Relevant academic research and scientific papers

Formation of a Pseudo-β-hairpin motif utilizing the Ant-pro reverse turn: Consequences of stereochemical reordering

Herein, we report a special case of pseudo-β-hairpin formation by tetrapetide sequences featuring a two-membered Ant-Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region. These folded structures uniquely feature the presence of C9- and C17-H-bonding patterns at reverse turn and interstrand regions, respectively. Their hairpin nucleation and folding propensities have been expounded using solution and solid state studies of distinct stereochemically altered sequences.