153976-26-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(6-Chloropyridin-2-yl)-4-methylpiperazine is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the creation of a wide range of medications, making it a valuable component in drug development.
Used in Agrochemical Production:
In the agricultural industry, 1-(6-Chloropyridin-2-yl)-4-methylpiperazine serves as a crucial intermediate in the production of agrochemicals. Its incorporation contributes to the development of effective solutions for pest control and crop protection.
Used in Central Nervous System Drug Development:
As a piperazine derivative, 1-(6-Chloropyridin-2-yl)-4-methylpiperazine holds potential for the development of drugs targeting the central nervous system. Its specific properties make it a promising candidate for further research and potential therapeutic applications.
Used in Antipsychotic and Anti-Inflammatory Research:
1-(6-Chloropyridin-2-yl)-4-methylpiperazine has been studied for its potential therapeutic properties, including antipsychotic and anti-inflammatory effects. Its ability to modulate specific biological pathways makes it a subject of interest for the development of novel treatments for various conditions.

Upstream product

• 109-01-3 1-methyl-piperazine 
• 2402-78-0 2,6-dichloropyridine 
• 20885-12-5 2-chloro-6-fluoropyridine 

Relevant academic research and scientific papers

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Negishi cross-coupling reactions catalyzed by an aminophosphine-based nickel system: A reliable and general applicable reaction protocol for the high-yielding synthesis of biaryls

Treatment of NMP solutions of NiCl2 with 1,1′,1″- (phosphanetriyl)tripiperidine (≈2.05 equiv), dissolved in THF, in air at 25°C forms a highly active catalytic system for the cross-coupling of a large variety of electronically activated, non-activated, deactivated, and ortho-substituted, heterocyclic, and functionalized aryl bromides and aryl chlorides with diarylzinc reagents. Very high levels of conversion and yields were obtained within 2 h at 60°C in the presence of only 0.1 mol% of catalyst (based on nickel) and thus at catalyst loadings far lower than typically reported for nickel-catalyzed versions of the Negishi reaction. Various aryl halides-which may contain trifluoromethyl groups, fluorides, or other functional groups such as acetals, ketones, ethers, esters, lactones, amides, imines, anilines, alkenes, pyridines, quinolines, and pyrimidines-were successfully converted into the corresponding biaryls. Electronic and steric variations are tolerated in both reaction partners. Experimental observations indicate that a molecular (NiI/NiIII) mechanism is operative.

Substituted nitrogen-containing heteroaryl derivatives useful as modulators of the histamine H4 receptor

The present invention relates to substituted nitrogen-containing heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using any of these derivatives and compositions for H4 receptor activity modulation and the tre

Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors

Arylpiperazines are nonselective agents that bind at 5-HT3 serotonin receptors with moderate to high affinity, whereas 1-phenylbiguanide is a low- affinity but more selective 5-HT3 agonist. In an attempt to enhance the affinity of th