153984-02-2Relevant articles and documents
Synthesis of Deoxydinucleoside Phosphates containing 6-Thio-substituted Purine Nucleobases
Clivio, Pascale,Fourrey, Jean-Louis,Favre, Alain
, p. 2585 - 2590 (2007/10/02)
An efficient preparative method to obtain, by the hydrogen phosphonate approach in solution, dinucleoside phosphates containing either 2'-deoxy-6-thioinosine or 2'-deoxy-6-thioguanosine at their 3' end, as in compounds 6 and 7, is described.For this purpose appropriate 5'-OH-free sulfur -modified deoxynucleoside intermediates required for this synthesis have been defined, as exemplified with the case of 2'-deoxy-6-thioguanosine.