153984-54-4

Basic information

• Product Name: phenyl 3,4-O-isopropylidene-1-thio-α-L-arabinopyranoside
• Synonyms: phenyl 3,4-O-isopropylidene-1-thio-α-L-arabinopyranoside
• CAS NO: 153984-54-4
• Molecular Weight: 282.361
• Mol File: 153984-54-4.mol

Chemical Properties

• CAS DataBase Reference: phenyl 3,4-O-isopropylidene-1-thio-α-L-arabinopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 3,4-O-isopropylidene-1-thio-α-L-arabinopyranoside(153984-54-4)
• EPA Substance Registry System: phenyl 3,4-O-isopropylidene-1-thio-α-L-arabinopyranoside(153984-54-4)

Safety Data

• Hazardous Substances Data: 153984-54-4(Hazardous Substances Data)

Upstream product

• 1233-03-0 1,2,3,4-tetra-O-acetyl-L-arabinopyranose 
• 98461-49-5 phenyl 2,3,4-tri-O-acetyl-1-thio-α-L-arabinopyranoside 
• 1233-03-0 1,2,3,4-tetra-O-acetyl-α-L-arabinopyranose 
• 108-98-5 thiophenol 
• 77-76-9 2,2-dimethoxy-propane 
• 122604-15-3 phenyl 1-thio-α-L-arabinopyranoside 

Downstream Products

• 952575-89-2 phenyl 2-O-levulinoyl-1-thio-β-L-arabinopyranoside 
• 1307876-26-1 C₃₃H₄₀O₁₂S 
• 1307876-25-0 C₂₉H₃₆O₁₀S 
• 1307876-24-9 C₃₂H₄₀O₁₀S 
• 1307876-18-1 C₁₈H₂₀Cl₃NO₇ 
• 1307876-17-0 C₂₂H₂₄O₆S 
• 1307876-16-9 C₂₁H₂₄O₄S 
• 1039374-23-6 phenyl 3,4-O-isopropylidene-2-O-(2-azidomethylbenzoyl)-1-thio-α-L-arabinopyranoside 
• 1039373-61-9 phenyl 3,4-O-isopropylidene-2-O-benzoyl-1-thio-α-L-arabinopyranoside 
• 321125-18-2 diosgenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->3)-2-O-acetyl-4-O-triethylsilyl-α-L-arabinopyranoside 
• 321125-17-1 diosgenin-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->4)-2-O-acetyl-3-O-triethylsilyl-α-L-arabinopyranoside 
• 321125-16-0 cholesterol-3-yl 2-O-(4-methoxybenzoyl)-3,4-di-O-triethylsilyl-β-D-xylopyranosyl-(1->4)-2-O-acetyl-3-O-triethylsilyl-α-L-arabinopyranoside 

Relevant articles and documents

Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment of several cancers. In the present study, we report on the synthesis of carbohydrate-based NK1R antagonists and their evaluation as anticancer agents against a wide range of cancer cells. All of the prepared compounds, derived from either-arabinose, have shown high affinity and NK1R antagonistic activity with a broad-spectrum anticancer activity and an important selectivity, comparable to Cisplatin. This strategy has allowed us to identify the galactosyl derivative 14α , as an interesting hit exhibiting significant NK1R antagonist effect (kinact0.209 ± 0.103 μM) and high binding affinity for NK1R (IC50= 50.4 nM,Ki= 22.4 nM by measuring the displacement of [125I] SP from NK1R). Interestingly, this galactosyl derivative has shown marked selective cytotoxic activity against 12 different types of cancer cell lines.

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