154047-46-8

Upstream product

• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 61-90-5 L-leucine 
• 124575-31-1 (S)-2-isobutyl-1-tosyl-aziridine 
• 130748-67-3 (2S)-N-(4-methylbenzene)-1-sulfonoamido-4-methylpentan-1-ol 
• 936012-04-3 (S)-N-(1-cyano-4-methylpentan-2-yl)-4-methylbenzenesulfonamide 
• 154047-36-6 (S)-1-(1,3-dithian-2-yl)-2-(4-methylbenzenesulfonamido)-4-methylpentane 

Downstream Products

• 936097-68-6 N-[1-(2-hydroxy-ethyl)-3-methyl-butyl]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

A convenient synthetic route to enantiopure N-tosylazetidines from α-amino acids

A general and convenient synthetic route to various chiral 2-substituted- and 2,4-disubstituted-N-tosylazetidines (ee >99%) is described in good overall yields starting from chiral α-amino acids using very simple chemistry.

Ring-opening of N-tosyl aziridines by 2-lithiodithianes

The reaction of lithiated dithianes 6-8 and 15 and 16 with enantiopure N-sulfonylated aziridines 1 and 2 leads via regiospecific nucleophilic ring-opening to enentiopure N-tosyl 2-(2'-dithianyl) secondary amines in good to excellent yields.These compounds