154048-89-2

Usage

Uses

Used in Organic Synthesis:
(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a key intermediate in the synthesis of various organic compounds, providing a versatile platform for the development of new chemical entities.
Used in Pharmaceutical Industry:
(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a building block for the preparation of pharmaceuticals, contributing to the discovery and development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a precursor in the synthesis of agrochemicals, aiding in the development of new pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Medicinal Chemistry:
(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a structural component in the design and synthesis of novel compounds for drug discovery, leveraging its unique properties to target specific biological pathways and mechanisms.
Used in Fine Chemicals Industry:
(4-IODO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER is used as a raw material in the production of fine chemicals, which are high-purity specialty chemicals used in various applications, including research, diagnostics, and the formulation of pharmaceuticals.

InChI:InChI=1/C10H13IN2O2/c1-10(2,3)15-9(14)13-8-6-12-5-4-7(8)11/h4-6H,1-3H3,(H,13,14)

Upstream product

• 56700-70-0 3-(tert-butoxycarbonylamino)pyridine 
• 462-08-8 pyridin-3-ylamine 
• 109-72-8 n-butyllithium 
• 20485-44-3 2,3-dimethyl-2,3-diaminobutane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 105752-11-2 4-iodopyridin-3-amine 

Downstream Products

• 344293-87-4 tert-butyl N-(4-mesityl-pyridin-3-yl)carbamate 
• 1210045-46-7 C₂₁H₂₄N₂O₂ 
• 1210045-43-4 tert-butyl 2-methyl-1H-pyrrolo[2,3-c]pyridine-1-carboxylate 
• 1260088-52-5 {4-[6-(5-fluoro-2-methoxyphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester 
• 1260094-21-0 [4-(4-hydroxy-6-methyl-6-phenyl-4-trifluoromethylhept-1-ynyl)pyridin-3-yl]carbamic acid tert-butyl ester 
• 1260094-66-3 {4-[6-(3-fluorophenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester 
• 1260095-04-2 {4-[6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester 
• 1260099-61-3 {4-[6-(5-bromoo-2-methoxyphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]pyridin-3-yl}carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of N-Substituted 3-Amino-4-halopyridines: A Sequential Boc-Removal/Reductive Amination Mediated by Br?nsted and Lewis Acids

N-Substituted 3-amino-4-halopyridines are valuable synthetic intermediates, as they readily provide access to imidazopyridines and similar heterocyclic systems. The direct synthesis of N-substituted 3-amino-4-halopyridines is problematic, as reductive aminations and base-promoted alkylations are difficult in these systems. A high yielding deprotection/alkylation protocol mediated by trifluoroacetic acid and trimethylsilyl trifluoromethanesulfonate is described, providing access to a wide scope of N-substituted 3-amino-4-halopyridines. This protocol furnishes many reaction products in high purity without chromatography. Similar reductive amination conditions were also established for deactivated anilines.

AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to amine-substituted heterocyclic compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., cancer) via inhibition of a methyltransfera

3-AMINO-PYRIDINES AS GPBAR1 AGONISTS

This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes

3-AMINO-PYRIDINES AS GPBAR1 AGONISTS

This invention relates to novel 3-aminopyridines of the formula (I) wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

HEPATITIS C INHIBITORS AND USES THEREOF

This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO

Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrat

Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds

The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula I, compositions containing compounds of formula I, and their use, for treating a patient suffering from, or subject to, a physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.

Cross coupling strategies towards the synthesis of the streptonigrin CD moiety

An efficient route to an appropriate model of the streptonigrin 4- phenylpyridine CD moiety is reported. 4-Chloro-3-nitropyridine was found to be the key precursor and its reactivity in cross coupling reactions was further investigated.