154057-57-5

Basic information

• Product Name: P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester
• Synonyms: P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester
• CAS NO: 154057-57-5
• Molecular Formula: C₂₃H₂₅FNO₃P
• Molecular Weight: 413
• Mol File: 154057-57-5.mol
• Article Data: 4

Chemical Properties

• Appearance: light yellow liquid
• Density: 1.239
• CAS DataBase Reference: P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester(154057-57-5)
• EPA Substance Registry System: P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester(154057-57-5)

Safety Data

• Hazardous Substances Data: 154057-57-5(Hazardous Substances Data)

Usage

General Description

P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester is a chemical compound that contains a cyclopropyl group, a fluorophenyl group, a quinolinyl group, and a phosphonic acid diethyl ester. It is commonly used as a pesticide and herbicide to control pests and weeds. P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester is known for its high efficacy and low toxicity, making it a popular choice for agricultural applications. Additionally, it has been found to have potential anti-inflammatory and anti-tumor properties, which makes it a subject of interest for pharmaceutical research. However, it is important to handle this compound with caution, as it may be harmful if ingested or inhaled, and poses a risk to the environment if not properly managed.

Upstream product

• 154057-56-4 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline 
• 122-52-1 triethyl phosphite 
• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 78-40-0 triethyl phosphate 

Downstream Products

• 1391833-12-7 (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one 
• 148516-15-8 (6S)-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}-5,6-dihydro-2H-pyran-2-one 
• 574705-92-3 sodium (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate 
• 147526-32-7 pitavastatin calcium salt 
• 147489-06-3 (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester 

Relevant articles and documents

Preparation method of statins intermediate

The invention discloses a preparation method of a statins intermediate, comprising the following steps: a phosphate compound and an aldehyde compound are subjected to a condensation reaction under theaction of a catalyst and alkali; after the reaction, post-treatment is conducted to obtain the statins intermediate. The statins intermediate includes a rosuvastatin intermediate (Compound A) and a pitavastatin calcium intermediate (Compound B). The preparation method has the advantages of low cost, simple operation and good yield, is environmentally friendly, and is suitable for industrial production.

The use of a lactonized statin side-chain precursor in a concise and efficient assembly of pitavastatin

A concise and simple synthetic route to pitavastatin is described. The approach involves a highly stereoselective Wittig olefination reaction between a lactonized statin side-chain precursor and the triphenylphosphonium bromide salt of the corresponding quinoline heterocyclic core. The necessary O-tert-butyl(dimethyl)silyl-protected pitavastatin lactone was obtained in 75% yield and high purity by simple crystallization from aqueous methanol. Subsequent deprotection, hydrolysis, and cation exchange in a one-pot operation provided pitavastatin calcium in 93% yield. Georg Thieme Verlag Stuttgart · New York.