15407-72-4

Upstream product

• 22847-91-2 11-α-hydroxyprogesterone 
• 5716-98-3 rac-3,3-ethanediyldioxy-14β,17ξH-pregn-5-ene-11,20-dione 
• 5716-98-3 rac-3,3-ethanediyldioxy-13α,17ξH-pregn-5-ene-11,20-dione 
• 124319-59-1 rac-3,3-ethanediyldioxy-11,20-dioxo-16,17-seco-13α-pregn-5-en-16-oic acid methyl ester 
• 114447-53-9 rac-3,3-ethanediyldioxy-13α,17ξH-pregn-5-ene-11,16,20-trione 
• 119657-91-9 rac-3,3-ethanediyldioxy-16-(toluene-4-sulfonyloxy)-13α-pregna-5,16-diene-11,20-dione 
• 124319-59-1 rac-3,3-ethanediyldioxy-11,20-dioxo-16,17-seco-14β-pregn-5-en-16-oic acid methyl ester 
• 114447-53-9 rac-3,3-ethanediyldioxy-14β,17ξH-pregn-5-ene-11,16,20-trione 
• 119657-91-9 rac-3,3-ethanediyldioxy-16-(toluene-4-sulfonyloxy)-14β-pregna-5,16-diene-11,20-dione 

Relevant academic research and scientific papers

New steroid 11-ketone group oxidation synthesizing process

The invention discloses a new steroid 11-ketone group oxidation synthesizing process. The method comprises that in a nonprotic organic solvent, under conditions of dimethyl sulfoxide (DMSO) as an oxidant, an organic alkali, dichlorophenyl phosphate and a piperidine aminoxyl free radical, a steroid 11-alpha hydroxyl compound is subjected to an oxidation reaction to generate a steroid 11-ketone group compound, the reaction temperature is -10 DEG C to a solvent reflux temperature, and the piperidine aminoxyl free radical is selected from the group consisting of a 2,2,6,6-tetramethylpiperidine-1-oxyl free radical or an analogue thereof.