154083-39-3Relevant academic research and scientific papers
Expedient Synthesis of Alphitolic Acid and Its Naturally Occurring 2- O-Ester Derivatives
Park, Somin,Cho, Jihee,Jeon, Hongjun,Sung, Sang Hyun,Lee, Seunghee,Kim, Sanghee
, p. 895 - 902 (2019)
The expedient synthesis of alphitolic acid (1) as well as its natural C-3-epimer and 2-O-ester derivatives was accomplished in a few steps from the readily commercially available betulin (9). A Rubottom oxidation delivered an α-hydroxy group in a stereo- and chemoselective manner. The diastereoselective reduction of the α-hydroxy ketone was key to accessing the 1,2-diol moiety of this class of natural products. Our concise and stereoselective synthetic protocol allowed the gram-scale synthesis of these natural products, which will facilitate future biological evaluations.
GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY
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Page/Page column 35-36, (2010/04/03)
The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds
