15409-53-7

Upstream product

• 583-60-8 2-Methylcyclohexanone 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 90112-65-5 2-hydroxymethyl-6-methyl-cyclohexanone 
• 15839-40-4 2-ethoxymethylene-6-methyl-cyclohexanone 
• 15839-41-5 2-diethoxymethyl-6-methyl-cyclohexanone 
• 86902-34-3 2-<<(trimethylsilyl)oxy>methylene>-6-methylcyclohexanone 
• 32116-70-4 2-butylthiomethylenecyclohexanone 
• 107647-58-5 2-Benzyl-3-methyl-cyclohex-1-enecarbaldehyde 
• 107647-57-4 1-Benzyl-2-methyl-6-[1-trimethylsilanyloxy-meth-(E)-ylidene]-cyclohexanol 
• 1352237-61-6 (E)-6-(tert-butoxymethylene)-2,2-dimethylcyclohexanone 
• 1431465-05-2 (E)-1-(3,3-dimethylcyclohex-1-enyl)but-2-en-1-one 
• 1431465-04-1 (E)-1-(3,3-dimethylcyclohex-1-enyl)but-2-en-1-ol 
• 1431465-03-0 1-(3,3-dimethylcyclohex-1-enyl)but-2-yn-1-ol 
• 1431464-92-4 1-(3,3-dimethylcyclohex-1-enyl)-2-methylbut-2-en-1-one 
• 1431464-91-3 1-(3,3-dimethylcyclohex-1-enyl)-2-methylbut-2-en-1-ol 
• 1431465-18-7 1-(3,3-dimethylcyclohex-1-enyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Catalytic asymmetric vinylation of ketone enolates.

[see reaction]. A protocol for the catalytic asymmetric vinylation of ketone enolates has been developed. Key to the success of this process was the development of new electron-rich chiral monodentate ligands.

Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction

Oxidative ring contraction of cyclic α-formyl ketones was facilitated by the action of H2O2under operationally simple and environmentally benign reaction conditions. The process was highly regioselective and enables stereospecific construction of contiguous quaternary all-carbon centers from stereodefined all-substituted all-cyclic ketones. The asymmetric syntheses of (+)-cuparene and (+)-tochuinyl acetate were also successively achieved by taking advantage of this novel protocol.

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Enantioselective total syntheses of (-)-taiwaniaquinone H and (-)-taiwaniaquinol B by iridium-catalyzed borylation and palladium-catalyzed asymmetric α-arylation

We report a concise, enantioselective total synthesis of (-)-taiwaniaquinone H and the first enantioselective total synthesis of (-)-taiwaniaquinol B by a route that includes asymmetric palladium-catalyzed α-arylation of a ketone with an aryl bromide that

Ring-Chain Tautomerism Provides a Route to 7a-Hydroxy-3a-methyl-2,7-dioxoperhydrobenzofuran. Synthesis of the Hydroxy γ-Lactone Substructure of Myrocin and Other Bioactive Natural Products

(2-Oxocyclohexyl)acetic acid 10 was converted into bicyclic alkoxy γ-lactones 12a-d via intermediate chloro lactone 11 and alkanolysis.Similarly, lactones 15a,b and 18 were prepared.In contrast, simple ring-chain tautomerism directly afforded the title heterocycle 28, a crystalline, stable and welldefined compound.The angular methyl group seems essential for the spontaneous lactonization. 5,5-Dialkoxy-4-oxocarboxylic acids 26a, b without an angular methyl group did not cyclize to bicyclic hydroxy γ-lactones. - Key Words: Hydroxy lactone, 5-membered, (lactol) tautomer / 4-Oxocarboxylic acids / Keto-cyclol tautomerism.