154092-64-5

Upstream product

• 100-51-6 benzyl alcohol 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 
• 154092-61-2 (S)-benzyl 2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid 

Downstream Products

• 681261-53-0 2S-(3-tert-butoxycarbonyl-2R-cyclopentylmethyl-propionylamino)-3,3-dimethyl-butyric acid benzyl ester 
• 230961-33-8 N₁-[(1S)-2,2-dimethyl-1-([((1R)-1-(3-pyridyl)ethyl)amino]carbonyl)propyl]-(N₄-hydroxy)-(2R)-2-{3-[3-methyl-(4-phenyl)phenyl]propyl}butanediamide 
• 230961-21-4 UK-370106 
• 230961-86-1 tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)-6-(3-methyl-4-phenylphenyl)hexanoate 
• 230961-47-4 (2R)-N₁-[(1S)-2,2-dimethyl-1-({[(1S)-2-methoxy-1-phenylethyl]amino}carbonyl)propyl]-2-{3-(3-methyl-4-phenylphenyl)propyl}-(N₄-3-propenyloxy)butanediamide 

Relevant academic research and scientific papers

Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes

Extension of the previously reported modification of Passerini multicomponent reaction (involving condensation with N-Boc-α-aminoaldehydes followed by a deprotection-transacylation step) to α-aminoacid derived carboxylic or isocyanide components, allowed the highly convergent and short synthesis of complex peptidomimetic structures, including known potent inhibitors of serine proteases.