154093-72-8Relevant articles and documents
Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones
Wagman, Allan S.,Cirz, Ryan,McEnroe, Glenn,Aggen, James,Linsell, Martin S.,Goldblum, Adam A.,Lopez, Sara,Gomez, Marcela,Miller, George,Simons, Lloyd J.,Belliotti, Thomas R.,Harris, Christina R.,Poel, Toni-Jo,Melnick, Michael J.,Gaston, Ricky D.,Moser, Heinz E.
, p. 1687 - 1692 (2017/10/09)
Conformationally constrained tetracyclic fluoroquinolones (FQs) were synthesized and profiled for their microbiological spectrum. The installation of a seven-membered ring between the pyrrolidine substituents and the C8 position on the FQ core scaffold resulted in a remarkable enhancement of microbiological potency toward both Gram-positive and Gram-negative bacteria. Focused optimization of seven-membered ring composition, stereochemistry, and amine placement led to the discovery of the two lead compounds that were selected for further progression.
5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE ANTIBACTERIALS
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Page/Page column 37, (2008/12/05)
The invention relates to novel chimeric antibiotics of formula (I) wherein R1 represents OH, OPO3H2 or OCOR5; R2 represents H, OH or OPO3H2; R3 represents H or halogen
QUINOLONECARBOXYLIC ACID COMPOUNDS, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF
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Page/Page column 8, (2010/11/26)
This invention discloses novel quinolonecarboxylic acid derivatives, pharmaceutically acceptable salts or hydrates thereof, and their preparation methods and medical uses. The compounds in this invention show potent antibacterial activity against broad-sp