154107-44-5

Upstream product

• 626-43-7 3,5-Dichloroaniline 

Downstream Products

• 89380-17-6 2-amino-4,6-dichloro-benzenesulfonamide 
• 1032648-28-4 2-amino-4,6-dichloro-N-{2,2,2-trifluoro-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]ethyl}benzenesulfonamide 
• 950776-03-1 2-benzyl-6,8-dichloro-1,1-dioxo-1,4-dihydro-2H-1λ6-benzo[1,2,4]thiadiazin-3-one 
• 1070341-67-1 2-amino-4,6-dichloro-N-((S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-ylamino]methyl}propyl)benzenesulfonamide 
• 1110272-42-8 2-amino-4,6-dichloro-N-(1-indol-1-ylmethyl-2-methylpropyl)-benzenesulfonamide 
• 1191032-68-4 2-amino-4,6-dichloro-N-{3-(2-chloro-1H-imidazol-1-yl)-1-[(4-methylpiperidin-1-yl)carbonyl]propyl}benzenesulfonamide 
• 1191032-69-5 2-amino-4,6-dichloro-N-{1-[(4-methylpiperidin-1-yl)carbonyl]-3-(2-nitro-1H-imidazol-1-yl)-propyl}benzenesulfonamide 
• 1070753-89-7 2-amino-4,6-dichloro-N{(S)-1-[(2,4-dimethylphenylamino)methyl]propyl}-benzenesulfonamide 
• 1070753-39-7 2-amino-4,6-dichloro-N-(2,2,2-trifluoro-1-p-tolylsulfanylmethylethyl)-benzenesulfonamide 

Relevant academic research and scientific papers

NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIAZIN-3ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to compounds of substituted-1,1-dioxo-benzo[1,2,4]thiadiazin-3-ones acting as a 5HT6 receptor antagonist, a preparation method thereof, and a pharmaceutical composition containing the same for treatment of the central nervous system disorders. The compounds of substituted-1,1-dioxo-benzo[1,2,4]thiadiazin-3-ones according to the present invention have excellent binding affinity for the 5HT6 receptor and excellent selectivity for the 5HT6 receptor over other receptors. Also, the compounds reverse a disruption of PPI by apomorphine and don't show rotatod deficit in mice. Therefore the compounds according to the present invention may be valuably used for treatment of a 5HT6 receptor relating disorders.

NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to compounds of substituted-1,1-dioxo-benzo[1,2,4]thiadiazin-3-ones acting as a 5HT6 receptor antagonist, a preparation method thereof, and a pharmaceutical composition containing the same for treatment of the central nervous system disorders. The compounds of substituted-1,1-dioxo-benzo[1,2,4]thiadiazin-3-ones according to the present invention have excellent binding affinity for the 5HT6 receptor and excellent selectivity for the 5HT6 receptor over other receptors. Also, the compounds reverse a disruption of PPI by apomorphine and don't show rotatod deficit in mice. Therefore the compounds according to the present invention may be valuably used for treatment of a 5HT6 receptor relating disorders.