1541168-95-9Relevant academic research and scientific papers
Asymmetric vinylogous mannich reaction of silyloxy furans with n - Tert -butanesulfinyl ketimines
Rao, V. U. Bhaskara,Jadhav, Amol P.,Garad, Dnyaneshwar,Singh, Ravi P.
supporting information, p. 648 - 651 (2014/03/21)
A highly regio- and diastereoselective TMSOTf promoted vinylogous Mannich reaction for the synthesis of chiral quaternary 3-aminooxindole butenolides from 2-silyloxy furans and chiral ketimines is described. The method is found to be very efficient and also provides a facile access to sterically challenging 3-aminooxindole butenolides bearing two quaternary centers in continuation. Further, the versatility of the method is demonstrated by the 1,4-addition of nucleophiles on the sterically congested butenolide substructure.
