154118-57-7Relevant academic research and scientific papers
Enantioselective synthesis of α-amino-γ-sulfonyl phosphonates with a tetrasubstituted chiral α-carbon via quinine-squaramide-catalyzed michael addition of nitrophosphonates to vinyl sulfones
Bera, Kalisankar,Namboothiri, Irishi N. N.
supporting information, p. 1265 - 1270 (2013/06/27)
α-Nitro-γ-sulfonyl phosphonates with a key tetrasubstituted chiral α-carbon center have been synthesized for the first time in high yield and enantioselectivity through a quinine-squaramide-catalyzed conjugate addition of α-nitro phosphonates to aryl vinyl sulfones. Representative examples presented here for the transformation of nitrosulfonyl phosphonates to aminosulfonyl phosphonates, alkylation at the α-position of the sulfonyl group followed by desulfonation and scale-up of the conjugate addition highlight the practical applications of the methodology. Copyright
