1541198-75-7

Upstream product

• 933585-58-1 3-bromo-5-chloro-benzoic acid methyl ester 
• 1541198-74-6 2-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)propan-2-ol 
• 230642-94-1 2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile 
• 188813-05-0 3-bromo-5-chloro-benzaldehyde 
• 14862-52-3 1,3-dibromo-5-chlorobenzene 

Downstream Products

• 1541198-78-0 ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride 
• 1541198-79-1 (S)-3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoic acid 
• 1541198-80-4 C₁₄H₂₀ClNO₃ 
• 1541198-83-7 (3S)-ethyl 3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate 
• 1541196-90-0 (3S)-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid 
• 1541198-81-5 (S)-ethyl 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propanoate hydrochloride 
• 1541198-76-8 3-amino-3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)propionic acid 
• 1541198-77-9 3-(3-chloro-5-(2-hydroxypropan-2-yl)phenyl)acrylic acid 

Relevant academic research and scientific papers

PYRAZOLE MAGL INHIBITORS

Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS

Disclosed herein are novel pharmaceutical agents which are useful as integrin receptor antagonists that mediate the pathologic processes of angiogenesis and fibrosis and as such are useful in pharmaceutical compositions and in methods for treating conditions mediated by these integrins by inhibiting or antagonizing these integrins. The novel pharmaceutical agents include those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods and intermediates useful for making the pharmaceutical agents and methods of using the pharmaceutical agents are also provided.