154122-65-3Relevant articles and documents
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain
Shao, Pengchang P.,Ok, Dong,Fisher, Michael H.,Garcia, Maria L.,Kaczorowski, Gregory J.,Li, Chunshi,Lyons, Kathryn A.,Martin, William J.,Meinke, Peter T.,Priest, Birgit T.,Smith, McHardy M.,Wyvratt, Matthew J.,Ye, Feng,Parsons, William H.
, p. 1901 - 1907 (2007/10/03)
A series of new voltage-gated sodium channel blockers were prepared based on the screening lead succinic diamide BPBTS. Replacement of the succinimide linker with the more rigid cyclic 1,2-trans-diamide linker was well tolerated. N-Methylation on the biph
1,2 DIAMIDO CYCLOALKYL SODIUM CHANNEL BLOCKERS
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, (2010/11/30)
1,2 Diamido cycloalkyl compounds that are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl thiazolidin-dione and aryl-link-aryl oxazolodine-dione compounds and a pharmaceutically acceptable carrier; and a method of treatment of acute pain, chronic pain, visceral pain, inflammatory pain, or neuropathic pain, as well as irritable bowel syndrome, Crohns disease, epilepsy, partial and generalized tonic seizures, multiple sclerosis, bipolar disease, and tachy-arrhythmias by the administration of an effective amount of aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolodine-dione compounds, either alone, or in combination with one or more therapeutically active compounds, are described.
SUBSTITUTED TRIAZOLINONES, TRIAZOLINETHIONES, AND TRIAZOLINIMINES AS ANGIOTENSIN II ANTAGONISTS
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, (2008/06/13)
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