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CAS

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154127-19-2

Brinzolamide, also known as (S)-Brinzolamide, is an isomer of Brinzolamide (B677601) and functions as a carbonic anhydrase inhibitor. It is primarily used as an antiglaucoma agent, helping to reduce intraocular pressure in the treatment of glaucoma.

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  • Brinzolamide Related Compound A (50 mg) ((S)-(-)-4-ethylamino-2,3-dihydro-2-(3-methoxypropyl)-4H-thieno-[3,2,e]-thiazine-6-sulfonamide-1,1-dioxide)

    Cas No: 154127-19-2

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  • 154127-19-2 Structure

  • Basic information

    1. Product Name: brinzolamide
    2. Synonyms: 2H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (S)-;Brinzolamide Related Compound A (50 mg) ((S)-(-)-4-ethylamino-2,3-dihydro-2-(3-methoxypropyl)-4H-thieno-[3,2,e]-thiazine-6-sulfonamide-1,1-dioxide);(S)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide;Brinzolamide impurityA;Brinzolamide (S)-isomer;(S)-Brinzolamide;(4S)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
    3. CAS NO:154127-19-2
    4. Molecular Formula: C12H21N3O5S3
    5. Molecular Weight: 383.51
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 154127-19-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 586°C at 760 mmHg
    3. Flash Point: 308.2°C
    4. Appearance: /
    5. Density: 1.5g/cm3
    6. Vapor Pressure: 1.03E-13mmHg at 25°C
    7. Refractive Index: 1.625
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 9.62±0.40(Predicted)
    11. CAS DataBase Reference: brinzolamide(CAS DataBase Reference)
    12. NIST Chemistry Reference: brinzolamide(154127-19-2)
    13. EPA Substance Registry System: brinzolamide(154127-19-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 154127-19-2(Hazardous Substances Data)

154127-19-2 Usage

Uses

Used in Pharmaceutical Industry:
Brinzolamide is used as an antiglaucoma agent for reducing intraocular pressure in patients with glaucoma. It works by inhibiting the enzyme carbonic anhydrase, which in turn decreases the production of aqueous humor in the eye, leading to a reduction in intraocular pressure and alleviating the symptoms of glaucoma.
Additionally, as a carbonic anhydrase inhibitor, brinzolamide may have potential applications in other areas where the inhibition of this enzyme could be beneficial, such as in the treatment of certain types of epilepsy or altitude sickness. However, these applications are not explicitly mentioned in the provided materials and would require further research and validation.

Check Digit Verification of cas no

The CAS Registry Mumber 154127-19-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,1,2 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 154127-19:
(8*1)+(7*5)+(6*4)+(5*1)+(4*2)+(3*7)+(2*1)+(1*9)=112
112 % 10 = 2
So 154127-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1

154127-19-2 Well-known Company Product Price

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  • USP

  • (1076374)  Brinzolamide Related Compound A  United States Pharmacopeia (USP) Reference Standard

  • 154127-19-2

  • 1076374-50MG

  • 14,578.20CNY

  • Detail

154127-19-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name brinzolamide, (R)-(+)-4-ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[2.3-e]-1,2-thiazine-6-sulfonamide-1,1dioxide

1.2 Other means of identification

Product number -
Other names (S)-(-)-4-ETHYLAMINO-2,3-DIHYDRO-2-(3-METHOXYPROPYL)-4H-THIENO-[3,2,E]-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:154127-19-2 SDS

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