154140-71-3

Usage

Uses

Used in Pharmaceutical Research:
4-Ethyl-1,2,3,4-tetrahydroisoquinoline is utilized as a building block in organic synthesis for the development of new pharmaceutical compounds. Its unique structure and properties make it a valuable component in the creation of novel drugs.
Used in Drug Discovery Research:
4-ETHYL-1,2,3,4-TETRAHYDROISOQUINOLINE is employed as a research tool in drug discovery, where its potential pharmacological properties are explored. Its role as a dopamine D2 receptor antagonist suggests it may contribute to the treatment of neurological and psychiatric disorders.
Used in Medicinal Chemistry:
4-Ethyl-1,2,3,4-tetrahydroisoquinoline is of interest in medicinal chemistry due to its potential anti-inflammatory and analgesic effects. These properties could lead to its use in the development of medications for pain relief and the treatment of inflammatory conditions.
Used in Neurological and Psychiatric Treatment:
As a dopamine D2 receptor antagonist, 4-Ethyl-1,2,3,4-tetrahydroisoquinoline may be used in the development of treatments for neurological and psychiatric disorders, where modulation of dopamine signaling is a therapeutic strategy.

InChI:InChI=1/C11H15N/c1-2-9-7-12-8-10-5-3-4-6-11(9)10/h3-6,9,12H,2,7-8H2,1H3

Upstream product

• 41219-10-7 4-ethylisoquinoline 
• 31601-81-7 4-ethenylisoquinoline 
• 503822-44-4 (1'R,4R)-4-ethyl-2-(2'-hydroxy-1'-phenylethyl)-1,2,3,4-tetrahydroisoquinoline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 350508-48-4 N-(o-bromobenzyl)-2α-(1'-propenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 350508-51-9 (5R,7aS,10R,11aR,12aS)-5-Ethyl-7,7,10-trimethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene 
• 350508-57-5 (1R,2S,5R)-2-[1-((R)-4-Ethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-methyl-ethyl]-5-methyl-cyclohexanol 
• 350508-35-9 (3R,4aR,5aS,6R,12aS)-6-Ethyl-3,12,12-trimethyl-2,3,4,4a,6,11,12,12a-octahydro-1H,5aH-5-oxa-11a-aza-naphthacene 
• 334706-53-5 N-crotyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 334706-50-2 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 203190-43-6 N-(o-bromobenzyl)-8-aminomenthol 
• 503822-35-3 (2R,4R)-2-(2-bromophenyl)-3-(but-2-enyl)-4-phenyl-1,3-oxazolidine 
• 503822-38-6 (3R,6R)-6-ethyl-3-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline 
• 1532-97-4 4-bromoisoquinoline 

Relevant academic research and scientific papers

Aryl radical cyclization of chiral 3-allyl-2-(2-bromophenyl)-1,3-oxazolidines with tributyltin hydride

Stereoselective radical cyclization of (4R)-3-allyl-2-(2-bromophenyl)-4-phenyl-1,3-oxazolidine promoted by the initiator/tributyltin hydride system constructed the chiral oxazolo[2,3-a]tetrahydroisoquinoline skeleton. These tricyclic compounds were transf

Synthesis of enantiopure mono- and disubstituted tetrahydroisoquinolines by 6-exo radical cyclizations

2-(o-Bromophenyl)-3-allyl- and 2-allyl-3-(o-bromobenzyl)-substituted perhydrobenzoxazines, derived from (-)-8-amino menthol, readily cyclized stereoselectively by reaction with tributyltin hydride in the presence of AIBN. The cyclization compounds were transformed into enantiopure 4-alkyl tetrahydroisoquinolines by reductive ring opening of the N,O-acetal moiety with lithium aluminum hydride. Enantiopure 1,4- and 3,4-dialkyl-substituted tetrahydroisoquinolines were also prepared by reaction of the cyclized compounds with methylmagnesium iodide and subsequent elimination of the menthol appendage.

Reduction of isoquinoline and pyridine-containing heterocycles with lithium triethylborohydride (Super-Hydride)

Isoquinolines, quinoline and pyridines are effectively reduced to 1,2,3,4-tetrahydroisoquinolines, 1,2,3,4-tetrahydroquinolines and piperidines respectively with lithium triethylborohydride (Super-Hydride). The mechanism of the reduction was explored by reduction of isoquinoline and pyridine with lithium triethylborodeuteride (Super-Deuteride).