154152-62-2

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 157069-75-5 3-(Benzyl-pyridin-3-yl-amino)-cyclohex-2-enone 
• 1584694-03-0 ethyl 2-amino-4-(5-chloro-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-5-oxo-1-(pyridin-3-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 
• 1584693-97-9 2-amino-4-(5-chloro-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-5-oxo-1-(pyridin-3-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1584694-02-9 ethyl 2-amino-4-(5-chloro-3-methyl-1-p-tolyl-1H-pyrazol-4-yl)-5-oxo-1-(pyridin-3-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 
• 1584693-96-8 2-amino-4-(5-chloro-3-methyl-1-p-tolyl-1H-pyrazol-4-yl)-5-oxo-1-(pyridin-3-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1584694-01-8 ethyl 2-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1-(pyridin-3-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate 
• 1584693-95-7 2-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1-(pyridin-3-yl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 

Relevant academic research and scientific papers

Synthesis of a novel class of some biquinoline pyridine hybrids via one-pot, three-component reaction and their antimicrobial activity

A small library of novel class of biquinoline containing pyridine moiety were synthesized by a one-pot cyclocondensation of 2-chloro-3-formyl quinoline, active methylene compounds and 3-(pyridine-3- ylamino)cyclohex-2-enone in the presence of catalytic am

Design, synthesis and molecular modeling of pyrazole-quinoline-pyridine hybrids as a new class of antimicrobial and anticancer agents

A new series of pyrazole-quinoline-pyridine hybrids were designed based on molecular hybridization technique and synthesized by a base-catalyzed cyclocondensation reaction through one-pot multicomponent reaction. All compounds were tested for in vitro ant

Design, synthesis and molecular modeling of biquinoline-pyridine hybrids as a new class of potential EGFR and HER-2 kinase inhibitors

A new series of biquinoline-pyridine hybrids were designed and synthesized by a base-catalyzed cyclocondensation through one-pot multicomponent reaction. All compounds were tested for in vitro anticancer activities against two cancer cell lines A549 (adenocarcinomic human alveolar basal epithelial) and Hep G2 (liver cancer). Enzyme inhibitory activities of all compounds were carried out against EGFR and HER-2 kinase. Of the compounds studied, majority of the compounds showed effective anticancer activity against used cancer cell lines. Compound 9i (IC50= 0.09 μM) against EGFR and (IC50= 0.2 μM) against HER-2 kinase displayed the most potent inhibitory activity as compared to other member of the series. In the molecular modelling study, compound 9i was bound in to the active pocket of EGFR with four hydrogen bonds and two π-cation interactions having minimum binding energy ΔGb= -54.4 kcal/mol.

Synthesis of Azacarbazoles

Photocyclization of N-Benzylenaminone (7) led to azacarbolinones products which were fragmented to unexpected aldehydes (9) and (11).