154164-39-3

Basic information

• Product Name: 1-(2-METHYL-4-NITRO-PHENYL)-1H-IMIDAZOLE
• Synonyms: 1-(2-METHYL-4-NITRO-PHENYL)-1H-IMIDAZOLE
• CAS NO: 154164-39-3
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.19736
• Mol File: 154164-39-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-METHYL-4-NITRO-PHENYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-METHYL-4-NITRO-PHENYL)-1H-IMIDAZOLE(154164-39-3)
• EPA Substance Registry System: 1-(2-METHYL-4-NITRO-PHENYL)-1H-IMIDAZOLE(154164-39-3)

Safety Data

• Hazardous Substances Data: 154164-39-3(Hazardous Substances Data)

Usage

General Description

1-(2-Methyl-4-nitro-phenyl)-1H-imidazole is a chemical compound with the molecular formula C9H8N4O2. It is a derivative of imidazole with a 2-methyl-4-nitrophenyl group attached to the nitrogen atom. 1-(2-METHYL-4-NITRO-PHENYL)-1H-IMIDAZOLE is commonly used in organic synthesis and pharmaceutical research. It is known for its potential antimicrobial and antifungal properties and has been studied for its potential use in the development of novel drugs. Additionally, it has also been investigated for its potential use as an inhibitor of certain enzymes and biological processes. The compound's unique structure and properties make it an interesting subject for further research and potential applications in various fields.

Upstream product

• 288-32-4 1H-imidazole 
• 455-88-9 5-nitro-2-fluorotoluene 

Downstream Products

• 1026300-98-0 N-(4-Imidazol-1-yl-5-methyl-2-nitro-phenyl)-acetamide 
• 143151-14-8 4-(1H-imidazol-1-yl)-5-methyl-2-nitroaniline 
• 154164-40-6 N-(4-Imidazol-1-yl-3-methyl-phenyl)-acetamide 
• 131885-80-8 4-Imidazol-1-yl-5-methyl-benzene-1,2-diamine 
• 461664-00-6 4-(1H-imidazol-1-yl)-3-methylaniline 

Relevant articles and documents

6-(1H-imidazol-1-yl)-7-nitro-2,3 (1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: Structure-activity relationships for the AMPA- type non-NMDA receptor

A novel series of quinoxalinediones possessing imidazolyl and related heteroaromatic substituents was synthesized and evaluated for their activity to inhibit [3H]AMPA binding from rat whole brain. From the structure- activity relationships, it was found that the 1H-imidazol-1-yl moiety could function as a bioisostere for the cyano and nitro groups, and that 6-(1H- imidazol-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (11) showed the most potent activity for the AMPA receptor. Compound 11 was evaluated for selectivity versus other excitatory amino acid receptors, and its action against AMPA at its receptor in the rat striatum was characterized. These data showed that compound 11 was a selective antagonist for the AMPA receptor with a K(i) value of 0.084 μM, being approximately equipotent with 2,3-dihydro-6-nitro- 7-sulfamoylbenzo(f)quinoxaline (3) (NBQX; K(i) = 0.060 μM). Compound 11 was also found to give protection against sound-induced seizure on DBA/2 mice at the minimum effective dose of 3 mg/kg ip (3; 10 mg/kg ip).