154179-86-9Relevant academic research and scientific papers
Nickel-Catalyzed Reductive Amidation of Unactivated Alkyl Bromides
Serrano, Eloisa,Martin, Ruben
, p. 11207 - 11211 (2016)
A user-friendly, nickel-catalyzed reductive amidation of unactivated primary, secondary, and tertiary alkyl bromides with isocyanates is described. This catalytic strategy offers an efficient synthesis of a wide range of aliphatic amides under mild conditions and with an excellent chemoselectivity profile while avoiding the use of stoichiometric and sensitive organometallic reagents.
