154189-40-9

Basic information

• Product Name: SIBENADET
• Synonyms: SIBENADET;4-Hydroxy-7-[2-[[2-[[3-(2-phenylethoxy)propyl]sulfonyl]ethyl]aMino]ethyl]-2(3H)-benzothiazolone;AR-C 68397;AR-C 68397XX;Viozan
• CAS NO: 154189-40-9
• Molecular Formula: C22H28N2O5S2
• Molecular Weight: 464.604
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 154189-40-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.311±0.06 g/cm3(Predicted)
• PKA: 8.71±0.20(Predicted)
• CAS DataBase Reference: SIBENADET(CAS DataBase Reference)
• NIST Chemistry Reference: SIBENADET(154189-40-9)
• EPA Substance Registry System: SIBENADET(154189-40-9)

Safety Data

• Hazardous Substances Data: 154189-40-9(Hazardous Substances Data)

Usage

Uses

Sibenadet is a dual D2 dopamine receptor agonist used in the treatment of obstructive pulmonary disease.

InChI:InChI=1S/C22H28N2O5S2/c25-19-8-7-18(21-20(19)24-22(26)30-21)9-11-23-12-16-31(27,28)15-4-13-29-14-10-17-5-2-1-3-6-17/h1-3,5-8,23,25H,4,9-16H2,(H,24,26)

Relevant articles and documents

Inhalation Atomizer Comprising a Blocking Function and a Counter

This invention presents an inhalation atomizer comprising a blocking function through a locking-mechanism and a counter along with a method to discharge and atomize fluid. The apparatus is accommodated in a two part housing, wherein the two parts are mounted to be rotatable relative to each other, and can be blocked through a locking mechanism. The locking mechanism is realized mainly by two protrusions. Protrusion A is located on the outer wall of the lower unit of the inside part. Protrusion B is located on the inner wall of counter. When the inhalation atomizer is actuated each time, the counter will make a rotation with a constant angle around the lower unit of the inside part. Once the predetermined number of actuations has been achieved, Protrusion A and Protrusion B will encounter with each other and hence the counter will be prevented from further rotation. Therefore, the inhalation atomizer is blocked and stopped from further use. The number of actuations of the device can be counted by the counter. Only when sufficient force is applied to destroy the device, this locking state of the device can be overcome. The inhalation atomizer in the current invention can be blocked suitably by this locking-mechanism.

TRANSCORNEAL SYSTEM FOR DELIVERY OF A PHARMACEUTICAL AGENT

The invention relates to a transcorneal system for delivery of a pharmaceutical agent, made from a matrix material forming a baseplate (1), said baseplate (1) being connected to a number of projections (4) for penetration of the Stratum corneum of the skin, said projections (4) being made from the matrix material and comprising the agent.

Propellant for Dosing Aerosols Comprising Packagings

The invention relates to a pharmaceutical product comprising a dosing aerosol containing a propellant, an effective quantity of adsorbent, a pharmaceutically active substance, substance formulation or substance mixture, and a packaging enclosing the adsorbent and the dosing aerosol with the pharmaceutically active substance, substance formulation or substance mixture.