1541898-18-3Relevant academic research and scientific papers
One-pot synthesis of isoquinoline and related compounds via Cu-mediated tandem cross-coupling and cyclization
Dhara, Shubhendu,Singha, Raju,Nuree, Yasin,Ray, Jayanta K.
, p. 795 - 798 (2014)
One-pot synthetic strategy has been developed to access isoquinolines and its analogs via Cu-mediated tandem cross-coupling and cyclization in good yields under mild reaction conditions. A mixture of suitably substituted α-bromoaldehyde, terminal alkyne, and aq NH3 in CuI/1,10-phenanathroline catalytic system afforded the 3-substituted isoquinoline regio-selectively in good to excellent yields.
