154195-54-7

Basic information

• Product Name: 7-(chloroacetyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
• Synonyms: 7-(chloroacetyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one;2H-1-BENZAZEPIN-2-ONE, 7-(2-CHLOROACETYL)-1,3,4,5-TETRAHYDRO-;OTAVA-BB 1087088;7-(2-chloro-acetyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one
• CAS NO: 154195-54-7
• Molecular Formula: C12H12ClNO2
• Molecular Weight: 237.685
• Mol File: 154195-54-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 475.8°C at 760 mmHg
• Flash Point: 241.5°C
• Appearance: /
• Density: 1.254g/cm³
• Vapor Pressure: 3.23E-09mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 7-(chloroacetyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(chloroacetyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(154195-54-7)
• EPA Substance Registry System: 7-(chloroacetyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(154195-54-7)

Safety Data

• Hazardous Substances Data: 154195-54-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H12ClNO2/c13-7-11(15)9-4-5-10-8(6-9)2-1-3-12(16)14-10/h4-6H,1-3,7H2,(H,14,16)

Upstream product

• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

COMPOSITIONS AND METHODS OF TARGETING MUTANT K-RAS

Compounds and compositions are presented that inhibit K-ras, and especially mutant K-ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES

This invention relates to compounds of the formula 1 wherein R1, R2, R7, R8, R9, U, V, Z, A, W, X, M, E, L, T and D are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.