1542-23-0 Usage
Description
4(1H)-Pyrimidinone, 5-fluoro-2,3-dihydro-2-thioxo(9CI) is a heterocyclic chemical compound with the molecular formula C4H3FN2OS. It incorporates a fluorine atom and a sulfur atom within its structure, which contributes to its unique properties and potential applications. Known for its antiviral and antitumor activities, this compound holds promise for the development of new drugs and medicinal compounds. Its diverse chemical properties and potential for biological activity also make it a candidate for use in agricultural and industrial applications.
Uses
Used in Pharmaceutical Industry:
4(1H)-Pyrimidinone, 5-fluoro-2,3-dihydro-2-thioxo(9CI) is used as a pharmaceutical intermediate for the development of antiviral and antitumor drugs due to its inherent biological activities. Its unique structure allows it to target specific viral and tumor cells, making it a valuable component in the creation of novel therapeutic agents.
Used in Agricultural Industry:
In the agricultural sector, 4(1H)-Pyrimidinone, 5-fluoro-2,3-dihydro-2-thioxo(9CI) is utilized as a bioactive compound in the development of pesticides or herbicides. Its potential to exhibit antiviral properties could be harnessed for controlling viral infections in crops, thereby improving agricultural productivity and crop health.
Used in Industrial Applications:
4(1H)-Pyrimidinone, 5-fluoro-2,3-dihydro-2-thioxo(9CI) is employed in various industrial applications, leveraging its chemical properties for uses such as catalysts in chemical reactions or as additives in the manufacturing of specific materials. Its versatility in chemical behavior offers a wide range of possibilities for its integration into industrial processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1542-23-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,4 and 2 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1542-23:
(6*1)+(5*5)+(4*4)+(3*2)+(2*2)+(1*3)=60
60 % 10 = 0
So 1542-23-0 is a valid CAS Registry Number.
1542-23-0Relevant articles and documents
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: Synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity
Bretner,Kulikowski,Dzik,Balinska,Rode,Shugar
, p. 3611 - 3617 (2007/10/02)
A convenient synthesis of 5-fluoro-2-thiouracil (11) is based on hydrolytic deamination of 5-fluoro-2-thiocytosine (9). Lewis acid-catalyzed condensation of di-TMS-5-fluoro-2-thiouracil (13) or di-TMS-2-thiouracil (14) with 2-deoxy-3,5-di-O-p-toluyl-D-ribofuranosyl chloride (15) led to mixtures of the β- and α-anomers of 3',5'-toluylated 2'-deoxy-5-fluoro-2-thiouridine (16 and 18) or 2'-deoxy-2-thiouridine (17 and 19), each of which was deblocked with MeOH-NH3 to give the desired free anomeric nucleoside pairs 1, 5 and 3, 7, respectively. These were selectively converted to the corresponding 5'-monophosphates 2, 6 and 4, 8, with the aid of the wheat shoot phosphotransferase system. Conformations of the nucleosides 1, 3, 5, 7 are deduced from 1H NMR spectra, and circular dichroism spectra for nucleotide anomeric pairs 2, 6 and 4, 8 are reported. Whereas β-2-thio-dUMP (4) was a good substrate (K(m) ? 10-5 M), β-5-fluoro-2-thio-dUMP (2) proved to be a potent competitive, slow-binding inhibitor (K(i) ? 10-8 M) of the purified enzymes from Ehrlich ascites carcinoma and L1210 cells. The α-anomer 6 was a weak inhibitor, with K(i) in the mM range, and its congener 8 hardly interacted with the enzyme. The β-anomer 1 exhibited antitumor activity in a mouse leukemic cell line L5178Y (IC50 ? 10-6 M), hence 40- 100-fold weaker than 5-fluoro-dUrd. Its α-anomer 5 was 10-fold less active, but exhibited at least 10-fold higher selectivity with respect to the tumor cells than the β-anomer 1.
