15-deoxy-Δ12,14-Prostaglandin J2-d4 (15-deoxy-Δ12,14-PGJ2-d4) is a deuterated analog of the naturally occurring 15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2), containing four deuterium atoms at the 3, 3'', 4, and 4'' positions. It is a metabolite of PGJ2 and is formed from PGD2 by the elimination of two molecules of water. 15-deoxy-Δ12,14-Prostaglandin J2-d4 is designed to serve as an internal standard for the quantification of its non-deuterated counterpart, 15-deoxy-Δ12,14-PGJ2, using gas chromatography (GC) or liquid chromatography (LC) mass spectrometry techniques. 15-deoxy-Δ12,14-PGJ2 exhibits selective binding to the peroxisome proliferator-activated receptor gamma (PPARγ) with an EC50 of 2 μM in a murine chimera system and is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 μM.
1542166-82-4
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Basic information
- Product Name: 15-deoxy-Δ12,14-Prostaglandin J2-d4
- Synonyms: 15-deoxy-Δ12,14-Prostaglandin J2-d4;VHRUMKCAEVRUBK-NSTSLKHFSA-N
- CAS NO:1542166-82-4
- Molecular Formula: C20H24D4O3
- Molecular Weight: 320.459167112
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1542166-82-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 15-deoxy-Δ12,14-Prostaglandin J2-d4(CAS DataBase Reference)
- NIST Chemistry Reference: 15-deoxy-Δ12,14-Prostaglandin J2-d4(1542166-82-4)
- EPA Substance Registry System: 15-deoxy-Δ12,14-Prostaglandin J2-d4(1542166-82-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1542166-82-4(Hazardous Substances Data)
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1542166-82-4 Usage
Uses
Used in Mass Spectrometry:15-deoxy-Δ12,14-Prostaglandin J2-d4 is used as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 in mass spectrometry applications, such as GCor LC-mass spectrometry. This allows for accurate measurement and analysis of the endogenous 15-deoxy-Δ12,14-PGJ2 levels in various biological samples.
Used in Research and Development:
In the field of pharmaceutical research and development, 15-deoxy-Δ12,14-Prostaglandin J2-d4 is utilized as a valuable tool for studying the biological activities and mechanisms of action of 15-deoxy-Δ12,14-PGJ2. This includes its role in PPARγ binding, lipogenesis, and adipocyte differentiation, which are important for understanding its potential therapeutic applications.
Used in Drug Discovery and Validation:
15-deoxy-Δ12,14-Prostaglandin J2-d4 can be employed in drug discovery and validation processes to identify and optimize compounds that modulate the activity of 15-deoxy-Δ12,14-PGJ2 or its target, PPARγ. This may lead to the development of novel therapeutics for various diseases and conditions, including those related to lipid metabolism and adipogenesis.
Used in Quality Control and Standardization:
In the pharmaceutical and biotechnology industries, 15-deoxy-Δ12,14-Prostaglandin J2-d4 can be used for quality control and standardization of assays and tests involving 15-deoxy-Δ12,14-PGJ2. This ensures the reliability and reproducibility of experimental results, which is crucial for the development and validation of new drugs and therapies.
Used in Analytical Method Development:
15-deoxy-Δ12,14-Prostaglandin J2-d4 can be employed in the development of new analytical methods for the detection and quantification of 15-deoxy-Δ12,14-PGJ2 and related compounds. This may involve the optimization of chromatographic separation techniques, mass spectrometry conditions, and other analytical parameters to achieve the desired sensitivity, selectivity, and accuracy for the analysis of these compounds in complex biological matrices.
Check Digit Verification of cas no
The CAS Registry Mumber 1542166-82-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,4,2,1,6 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.Calculate Digit Verification of CAS Registry Number 1542166-82:
(9*1)+(8*5)+(7*4)+(6*2)+(5*1)+(4*6)+(3*6)+(2*8)+(1*2)=154
154 % 10 = 4
So 1542166-82-4 is a valid CAS Registry Number.
1542166-82-4Upstream product
1542166-82-4Downstream Products
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15-deoxy-Δ12,14-Prostaglandin J2-d4
