1542232-47-2Relevant academic research and scientific papers
Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds - Synthesis and in vitro metabolism of deuterated derivatives of dronedadrone
Schofield, Joseph,Brasseur, Denis,De Bruin, Beatrice,Vassal, Thierry,Klieber, Sylvie,Arabeyre, Catherine,Bourrie, Martine,Sadoun, Freddy,Fabre, Gerard
, p. 504 - 512 (2014/03/21)
The synthesis and in vitro metabolism studies of a family of specifically deuterated derivatives of dronedarone are described. Metabolic stability and clearance of the parent compound are not sensitive to deuterium substitution, irrespective of the position of the heavy label. Copyright
