1542233-50-0Relevant academic research and scientific papers
Guanidine-catalyzed γ-selective morita-baylis-hillman reactions on α,γ-dialkyl-allenoates: Access to densely substituted heterocycles
Selig, Philipp,Turo?kin, Aleksej,Raven, William
, p. 2535 - 2539 (2013)
N-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD) was discovered as an excellent catalyst for the Morita-Baylis-?-Hillman reaction for previously hard-to-activate α,γ-dialkyl allenoate substrates. The obtained densely substituted allenic alcohols, which are generally inaccessible with other Lewis base catalysts, could be further converted into 2,5-dihydrofuran and 2H-pyran-2-one heterocyclic structures with challenging substitution patterns. Georg Thieme Verlag Stuttgart · New York.
